Central skull base osteomyelitis due to nasopharyngeal Klebsiella infection

Abstract

Skull base osteomyelitis (SBO) is a rare but life-threatening disease usually seen as a complication of otitis externa [1]. It initially involves the lateral part of the temporal bone and extends to the petrous apex and clivus [2], accompanied by bone erosion, thrombophlebitis, and hematogenous seeding [3]. Thus, patients with SBO typically present with otalgia, otorrhea, hearing loss, and cranial nerve dysfunction in the immunocompromised, particularly older diabetic patients [4]. Central skull base osteomyelitis due to nasopharyngeal Klebsiella infection Kyoung-Nam Woo, MD; Jieun Roh, MD; Seung-Kug Baik, PhD; Dong-Hyeon Shin, MD; Ki-Seok Park, MD; Min-Gyu Park, PhD; Kyung-Pil Park, PhD; Sung-Ho Ahn, MD Department of Neurology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Busan, Republic of Korea Department of Radiology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Busan, Republic of Korea CASE REPORT