Dialysis Access and Preemptive Kidney Transplantation

Y. Mochizuki, Y. Miyata, T. Matsuda, Y. Mukae, K. Ohba, H. Sakai
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Abstract

Sustainable vascular or peritoneal access for dialysis is very important for patients undergoing dialysis therapy, and access trouble is occasionally involved with unexpected occurrence of complications. Once access trouble occurs, dialysis therapy might be discontinued and be followed by a life-threatening state of patients with end-stage kidney disease. Bacterial infection, massive bleeding, and thrombosis in patients undergoing hemodialysis and acute infectious peritonitis and chronic encapsulating peritoneal sclerosis in patients undergoing peritoneal dialysis are important clinical issues. Preemptive kidney transplantation prior to dialysis has several advantages over transplantation after exposure to dialysis therapy. One of the notable advantages is the lack of necessity of dialysis access, which avoids access operations before transplantation. However, some transplant recipients may need short-term dialysis therapy due to the unexpected progression of chronic renal dysfunction. Dialysis access is required in a short preoperative period for preconditioning. The selection of renal replacement therapy without complications in a short-term dialysis before transplant surgery is important for the success of kidney transplantation. Appropriate preparation of short-term dialysis therapy and access is a key to success of preemptive kidney transplantation.
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透析途径与预防性肾移植
持续的血管或腹膜透析通路对接受透析治疗的患者非常重要,而通道困难有时涉及意外并发症的发生。一旦出现获取困难,透析治疗可能会中断,终末期肾病患者可能会进入危及生命的状态。血液透析患者的细菌感染、大出血、血栓形成以及腹膜透析患者的急性感染性腹膜炎和慢性包裹性腹膜硬化症是重要的临床问题。在透析前进行先发制人的肾移植比透析治疗后进行移植有几个优点。其中一个显著的优点是不需要透析通道,这避免了移植前的通道手术。然而,由于慢性肾功能障碍的意外进展,一些移植受者可能需要短期透析治疗。需要在术前短时间内进行透析以进行预处理。肾移植术前短期透析选择无并发症的肾替代疗法对肾移植的成功至关重要。适当的短期透析治疗的准备和获得是先发制人肾移植成功的关键。
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