Yuxiao Tang , Xiaobin Zhuo , Yan Cao , Diya Lv , Langdong Chen , Yinyin Zhang , Jianxin Yang , Hui Shen , Xin Dong , Dongyao Wang
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引用次数: 0
Abstract
The natural product baicalein derivative baicalein-8-sulfonic acid (BaSO3H) showed significant inhibitory effects on hepatocarcinoma cells viabilities and colony formation, but its molecular target(s) and mechanism were still not clearly elucidated. Using a DNA-programmed photoaffinity labeling method, we identified 12 targets that specifically bound with BaSO3H. Among these, BaSO3H bound with c-Jun N-terminal kinase 2 (JNK2) at an affinity of 33.1 nM (Kd) to induce apoptosis and autophagy in hepatocarcinoma cells.
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