Don't forget arterial thrombosis in patients with COVID-19: A case series

Q4 Medicine Thrombosis Update Pub Date : 2021-12-01 DOI:10.1016/j.tru.2021.100065

Daniel D. Gold , Ramzi Kurd , Sharon Einav

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引用次数: 4

Abstract

Introduction

The acute disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS COV-2) is accompanied by a hypercoagulable state. Multiple publications have described the venous thromboembolic events associated with coronavirus disease 2019 (COVID-19) but arterial thromboembolic events have yet to be described.

Cases description

We describe five COVID-19 patients that developed severe morbidity as a result of occlusive arterial thromboembolic events occurring despite treatment with low molecular weight heparin. All cases presented with an acute confusional state and were accompanied by rapid elevations of lactate and D-dimers and leukocytes. The end organs involved were the kidneys, spleen, liver, lungs, central nervous system, intestines and limbs. Only one of the five patients survived.

Conclusion

COVID-19 is associated with not only venous but also arterial thromboembolic events. Further research is required to clarify the incidence, causes and possible modes of prevention of this potentially lethal disease complication.

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不要忘记COVID-19患者的动脉血栓形成:病例系列

由严重急性呼吸综合征冠状病毒2型(SARS COV-2)引起的急性疾病伴有高凝状态。多个出版物描述了与2019冠状病毒病(COVID-19)相关的静脉血栓栓塞事件，但尚未描述动脉血栓栓塞事件。病例描述我们描述了5例COVID-19患者，尽管使用低分子肝素治疗，但仍发生闭塞性动脉血栓栓塞事件，导致严重发病率。所有病例均表现为急性神志不清，并伴有乳酸、d -二聚体和白细胞的快速升高。累及的终末器官有肾、脾、肝、肺、中枢神经系统、肠和四肢。五名患者中只有一人幸存。结论covid -19不仅与静脉血栓栓塞事件有关，而且与动脉血栓栓塞事件有关。需要进一步的研究来阐明这种潜在致命疾病并发症的发生率、原因和可能的预防模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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