Na Liu, Yajie Sun, Yulin Sun, Yilin Sun, Ting Luo, Fengying Yang, Peng Wang, Di Ge
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引用次数: 0
Abstract
: A total of 23 diterpenoids were isolated from the seeds of Euphorbia lathyris , and one new compound ( 1 ) and twenty-two known compounds ( 2-23 ) were characterized by using 1D- and 2D-NMR spectra and HRESIMS analysis. Cytotoxicity of the isolated compounds against BT-549 and MDA-MB-231 cancer cells lines were evaluated further. Compounds 3 , 10 , 14 , and 22 were found to exhibit considerable cytotoxic activities against BT-549 cells, with IC 50 values ranging from 4.7 to 10.1 μM. Compounds 1 , 2 , 14 and 22 were able to inhibit the MDA-MB-231 cell line growth with IC 50 values of 5.7 to 21.3 μM, while other compounds showed no obvious inhibitory effects.
期刊介绍：
Records of Natural Products is a journal of natural product chemistry. Reviews, book reviews, research papers and short reports are considered on the substances of plants, microbes and animals.
Discussions on the structure elucidation, synthesis of naturally occurring compounds and biological activity of natural compounds and plant extracts, biosynthesis of natural products and essential oils of aromatic plants as well as chemotaxonomy in the field of plants are welcomed in the journal.
All published research articles in Records of Natural Products have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by expert referees.
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