Shueh Wah Kennedy, Namita Roy Choudhury, Rajarathinam Parthasarathy
{"title":"3D printing soft tissue scaffolds using Poly(caprolactone)","authors":"Shueh Wah Kennedy, Namita Roy Choudhury, Rajarathinam Parthasarathy","doi":"10.1016/j.bprint.2023.e00259","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>The creation of tissue scaffolds complex enough to facilitate acceptable tissue repair is difficult with analogue production methods, but the trend of </span>computer aided design<span> and 3D printing shows promise for rapidly creating customisable, complex scaffolds. This review discusses recent advances in 3D printing biodegradable soft tissue scaffolds, focusing on poly(caprolactone) (PCL) as a major component of scaffolds for dermal, </span></span>adipose<span>, and muscle repair. PCL is a biodegradable polyester<span> used in bone and other hard tissue scaffolds. However, creating softer blends and copolymers with PCL has enabled wider application in soft tissue-engineered scaffolds. The review begins with the challenges and requirements of soft tissue-engineered scaffolds, followed by new techniques and materials from recent work. The primary methods of printing soft scaffolds are highlighted, such as extrusion-based, liquid polymerisation based and bioprinting, with multi-material printing being a more recent trend featuring combinations of the previous methods.</span></span></p></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioprinting","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405886623000027","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Computer Science","Score":null,"Total":0}
引用次数: 5
Abstract
The creation of tissue scaffolds complex enough to facilitate acceptable tissue repair is difficult with analogue production methods, but the trend of computer aided design and 3D printing shows promise for rapidly creating customisable, complex scaffolds. This review discusses recent advances in 3D printing biodegradable soft tissue scaffolds, focusing on poly(caprolactone) (PCL) as a major component of scaffolds for dermal, adipose, and muscle repair. PCL is a biodegradable polyester used in bone and other hard tissue scaffolds. However, creating softer blends and copolymers with PCL has enabled wider application in soft tissue-engineered scaffolds. The review begins with the challenges and requirements of soft tissue-engineered scaffolds, followed by new techniques and materials from recent work. The primary methods of printing soft scaffolds are highlighted, such as extrusion-based, liquid polymerisation based and bioprinting, with multi-material printing being a more recent trend featuring combinations of the previous methods.
期刊介绍：
Bioprinting is a broad-spectrum, multidisciplinary journal that covers all aspects of 3D fabrication technology involving biological tissues, organs and cells for medical and biotechnology applications. Topics covered include nanomaterials, biomaterials, scaffolds, 3D printing technology, imaging and CAD/CAM software and hardware, post-printing bioreactor maturation, cell and biological factor patterning, biofabrication, tissue engineering and other applications of 3D bioprinting technology. Bioprinting publishes research reports describing novel results with high clinical significance in all areas of 3D bioprinting research. Bioprinting issues contain a wide variety of review and analysis articles covering topics relevant to 3D bioprinting ranging from basic biological, material and technical advances to pre-clinical and clinical applications of 3D bioprinting.
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