Yujia Shang , Shiou Zhu , Fangfei Nie , Yonghuan Zhen , Pengbing Ding , Dong Li , Hua Li , Yang An
{"title":"Prospective application of poloxamer 188 in plastic surgery: A comprehensive review","authors":"Yujia Shang , Shiou Zhu , Fangfei Nie , Yonghuan Zhen , Pengbing Ding , Dong Li , Hua Li , Yang An","doi":"10.1016/j.cjprs.2022.01.001","DOIUrl":null,"url":null,"abstract":"<div><p>An increasing number of researchers have demonstrated that poloxamer 188 (P188) can be used as a pharmaceutical excipient for clinical applications. Its membrane-sealing effects and inherent biological activities make it an extremely promising agent for plastic surgery. In this review, we summarize the positive roles of P188 in autologous fat grafting, wound healing, and cartilage transplantation. These roles include improving the survival rate of fat grafts and chondrocytes, stimulating the metabolic activity of adipocytes, promoting wound healing, and contributing to cartilage formation. Although further research is still needed, it is clear that P188 has great potential and application value in the field of plastic surgery.</p></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"4 1","pages":"Pages 31-37"},"PeriodicalIF":0.0000,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2096691122000012/pdfft?md5=a3f096b3c28d576b1764b54f944b99e9&pid=1-s2.0-S2096691122000012-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Journal of Plastic and Reconstructive Surgery","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2096691122000012","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
An increasing number of researchers have demonstrated that poloxamer 188 (P188) can be used as a pharmaceutical excipient for clinical applications. Its membrane-sealing effects and inherent biological activities make it an extremely promising agent for plastic surgery. In this review, we summarize the positive roles of P188 in autologous fat grafting, wound healing, and cartilage transplantation. These roles include improving the survival rate of fat grafts and chondrocytes, stimulating the metabolic activity of adipocytes, promoting wound healing, and contributing to cartilage formation. Although further research is still needed, it is clear that P188 has great potential and application value in the field of plastic surgery.
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