{"title":"Uptake of Host Metabolic Succinate Correlates with Salmonella Virulence Induction","authors":"Y. Choi, Y. Koh","doi":"10.4167/JBV.2021.51.1.037","DOIUrl":null,"url":null,"abstract":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ license/by-nc/3.0/). Accumulation of succinate promotes Salmonella pathogenic program during intracellular infection. Using RNA-seq, increased mRNA expression of the genes in pmrAB and Salmonella pathogenicity island2 (SPI-2) regulon is measured in succinate-containing medium. Furthermore, uptake of host metabolic succinate through DcuB transporter also induces program for Salmonella virulence. Thus, succinate is major factor of Salmonella enterica serovar Typhimurium (S.Tm) virulence induction.","PeriodicalId":39739,"journal":{"name":"Journal of Bacteriology and Virology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Bacteriology and Virology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4167/JBV.2021.51.1.037","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Immunology and Microbiology","Score":null,"Total":0}
引用次数: 0
Abstract
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ license/by-nc/3.0/). Accumulation of succinate promotes Salmonella pathogenic program during intracellular infection. Using RNA-seq, increased mRNA expression of the genes in pmrAB and Salmonella pathogenicity island2 (SPI-2) regulon is measured in succinate-containing medium. Furthermore, uptake of host metabolic succinate through DcuB transporter also induces program for Salmonella virulence. Thus, succinate is major factor of Salmonella enterica serovar Typhimurium (S.Tm) virulence induction.
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