{"title":"Research progress in Gasdermin family proteins and their association with diseases","authors":"R. Tao, Wei Li, S. Shang","doi":"10.3760/CMA.J.ISSN.0254-5101.2019.10.010","DOIUrl":null,"url":null,"abstract":"Gasdermin family (GSDMs), consisting of six proteins (GSDMA, GSDMB, GSDMC, GSDMD, GSDME and DFNB59) in humans and ten proteins (GSDMA1-3, GSDMC1-4, GSDMD, GSDME and DFNB59) in mice, might be involved in multiple physiological and pathological processes, including epithelial cell development, apoptosis, inflammation, carcinogenesis and immune-related diseases. Recent studies confirmed GSDMD, which containing an N-terminal domain with pore-forming activity and a C-terminal domain with structural autoinhibition, as a crucial substrate of inflammatory caspases in pyroptosis, pioneering a new area for structural and functional research on Gasdermin family proteins. This review will summarize the latest progress in the structures, functions and association with diseases of several Gasdermin family proteins. \n \nKey words: \nGasdermin family; Pyroptosis; Inflammatory caspase; Gasdermin D (GSDMD)","PeriodicalId":10089,"journal":{"name":"中华微生物学和免疫学杂志","volume":"39 1","pages":"784-787"},"PeriodicalIF":0.0000,"publicationDate":"2019-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华微生物学和免疫学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.0254-5101.2019.10.010","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Immunology and Microbiology","Score":null,"Total":0}
引用次数: 1
Abstract
Gasdermin family (GSDMs), consisting of six proteins (GSDMA, GSDMB, GSDMC, GSDMD, GSDME and DFNB59) in humans and ten proteins (GSDMA1-3, GSDMC1-4, GSDMD, GSDME and DFNB59) in mice, might be involved in multiple physiological and pathological processes, including epithelial cell development, apoptosis, inflammation, carcinogenesis and immune-related diseases. Recent studies confirmed GSDMD, which containing an N-terminal domain with pore-forming activity and a C-terminal domain with structural autoinhibition, as a crucial substrate of inflammatory caspases in pyroptosis, pioneering a new area for structural and functional research on Gasdermin family proteins. This review will summarize the latest progress in the structures, functions and association with diseases of several Gasdermin family proteins.
Key words:
Gasdermin family; Pyroptosis; Inflammatory caspase; Gasdermin D (GSDMD)
Gasdermin家族(GSDMs)在人体中包含6个蛋白(GSDMA、GSDMB、GSDMC、GSDMD、GSDME和DFNB59)，在小鼠中包含10个蛋白(GSDMA1-3、GSDMC1-4、GSDMD、GSDME和DFNB59)，可能参与多种生理病理过程，包括上皮细胞发育、凋亡、炎症、致癌和免疫相关疾病。近年来的研究证实，GSDMD是炎性caspase在焦亡过程中的重要底物，其含有具有成孔活性的n端结构域和具有结构自抑制作用的c端结构域，为Gasdermin家族蛋白的结构和功能研究开辟了新的领域。本文就几种Gasdermin家族蛋白的结构、功能及其与疾病的关系的最新进展作一综述。关键词:Gasdermin家族;Pyroptosis;炎症细胞凋亡蛋白酶;Gasdermin D (GSDMD)
期刊介绍：
Chinese Journal of Microbiology and Immunology established in 1981. It is one of the series of journal sponsored by Chinese Medical Association. The aim of this journal is to spread and exchange the scientific achievements and practical experience in order to promote the development of medical microbiology and immunology. Its main contents comprise academic thesis, brief reports, reviews, summaries, news of meetings, book reviews and trends of home and abroad in this field. The distinguishing feature of the journal is to give the priority to the reports on the research of basic theory, and take account of the reports on clinical and practical skills.
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