M. Kanou, Katsuyuki Nakamura, Kyohei Horie, H. Sakai, Yuta Yanagihara, Iori Sakakibara, K. Yamana, Yuuki Imai
{"title":"Polyamine pathway is associated with muscle anabolic effects by androgen receptor ligand","authors":"M. Kanou, Katsuyuki Nakamura, Kyohei Horie, H. Sakai, Yuta Yanagihara, Iori Sakakibara, K. Yamana, Yuuki Imai","doi":"10.1002/rco2.28","DOIUrl":null,"url":null,"abstract":"Muscle wasting is a common condition concomitant with aging. Androgens significantly increase skeletal muscle mass, but the role of the androgen receptor (AR) in skeletal muscle is not well established. TEI‐SARM2, a novel selective androgen receptor modulator (SARM), was developed as a pharmaceutical candidate for the treatment of muscle wasting diseases.","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"4 1","pages":"57 - 74"},"PeriodicalIF":0.0000,"publicationDate":"2020-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/rco2.28","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JCSM rapid communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/rco2.28","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Muscle wasting is a common condition concomitant with aging. Androgens significantly increase skeletal muscle mass, but the role of the androgen receptor (AR) in skeletal muscle is not well established. TEI‐SARM2, a novel selective androgen receptor modulator (SARM), was developed as a pharmaceutical candidate for the treatment of muscle wasting diseases.
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