Estimación de la perfusión de hígado e íleon terminal con microesferas coloreadas, comparando asistencias mecánicas circulatorias de flujo continuo y pulsátil

Abstract

Objective

To estimate blood flow in the small intestine and liver by administration of coloured microspheres in the left atrium, comparing this estimate with continuous flow perfusion and pulsatile flow, in order to confirm or reject hypoperfusion and hypoxia in these organs attributed to loss of pulse amplitude as the cause of Heyde's syndrome.

Material and method

Twenty-two minipig pigs of both sexes weighing 29.5 ± 9.6 kg were implanted with 11 continuous and 11 pulsatile mechanical circulatory assist devices were implanted in 22 minipig. Haemodynamic and analytic parameter were measured. Liver and terminal ileum blood perfusión was estimated by administration of stained microspheres previus to circulatory support, at 30 minutes of full assist and at 30 minutes of partial assist.

Results

Data were reported as percent of estimated perfusion at baseline. The study was performed by analysis of variance for repeated measures with a significance α of 0.05. In the liver, type of assistance (total or partial), type of pump (continuous or pulsatile) and the interaction between the 2 had the following statistical significance: 0.518. 0.364 and 0.237 respectively. In the terminal ileum the results were: 0.264. 0.193 and 0.141.

Analytically significant differences were observed in bilirubin level related to the continuous flow pump, as well as pH and urea.

Conclusions

We observed no significant differences in the estimation of perfusion in ileum and liver when comparing continuous flow and pulsatile flow CMA.