Effect of Ischemia-Induced Cochlear Inflammation on Auditory Responses in Male Rats

IF 0.4 Q4 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY Auditory and Vestibular Research Pub Date : 2021-12-25 DOI:10.18502/avr.v31i1.8135

H. Fanaei, A. Pourbakht, Sadegh Jafarzadeh

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Abstract

Background and Aim: Ischemic injury is a major cause of hearing loss and oxidative stress is an important part of ischemic injury. The goal of this study was to evaluate the cochlear oxidative stress effect on auditory responses in male rats. Methods: Cochlear oxidative stress was induced by bilateral carotid artery occlusion for 20 minutes. The rats were evaluated by biochemical inflammatory factors tumor necrosis factor-α [TNF-α] and C-reactive protein (CRP) in the day before and 1st, 4th, and 7th days following surgery. The auditory brainstem response (ABR) and electrocochleography (ECochG) were evaluated on the day before surgery and 14th, 21th and 28th days after surgery. Results: TNF-α and CRP levels concentrations increased one day after ischemia and subsequently decreased on the 7th day. The click and tone burst evoked ABR showed increased thresholds on day14th, 21th, and 28th. The highest threshold was recorded on day14th. The ECochG results also were abnormal for 55%, 70%, and 45% of cases on day 14th, 21th, and 28th, respectively. Conclusion: Cochlear oxidative stress affects hearing sensitivity. The ABR shows elevated thresholds and abnormal ECochG was found in many cases.

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缺血性耳蜗炎症对雄性大鼠听觉反应的影响

背景与目的:缺血性损伤是听力损失的主要原因，氧化应激是缺血性损伤的重要组成部分。本研究旨在探讨雄性大鼠耳蜗氧化应激对听觉反应的影响。方法:双侧颈动脉闭塞20分钟诱导耳蜗氧化应激。于手术前一天及术后第1、4、7天采用生化炎症因子肿瘤坏死因子-α (TNF-α)、c反应蛋白(CRP)进行评价。分别于术前1天和术后第14、21、28天评估听脑反应(ABR)和耳蜗电图(ECochG)。结果:缺血后第1天TNF-α、CRP水平升高，第7天下降。在第14天、第21天和第28天，咔哒声和音调爆发诱发的ABR阈值升高。第14天阈值最高。第14天、第21天和第28天ECochG结果异常的分别为55%、70%和45%。结论:耳蜗氧化应激影响听敏。ABR显示阈值升高，ECochG异常。

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