The effects of sleeve gastrectomy on renal function in diabetic and non-diabetic morbidly obese patients

Abstract

Introduction: Obesity is associated with albuminuria and impaired renal function. Bariatric surgery has been shown to improve and resolve diabetes and improve renal function in patients with morbid obesity. This study investigates the potential effects of sleeve gastrectomy on the improvement of renal function and albuminuria in diabetic and non-diabetic morbidly obese patients and discusses probable mechanisms. Material and methods: This prospective study included, 137 morbidly obese patients (44 diabetics and 93 non-diabetic) who underwent laparoscopic sleeve gastrectomy who were evaluated clinically (anthropometric measurements) and biochemically before surgery and at 1 year from surgery. Results: Sleeve gastrectomy significantly decreases weight and body mass index, improves glycemic parameters, hyperfiltration, and urinary albumin excretion in diabetic and non-diabetic patients; (P < 0.001). Alterations in C- reactive protein (CRP) levels are strongly associated with ACR decline in diabetic patients. Conclusion: Our findings revealed significant decreases in weight, body mass index, and glycemic parameters after sleeve gastrectomy in diabetic and non-diabetic patients, accompanied by the resolve of hyperfiltration, urinary albumin excretion, and improvement of renal function via reduction of the systemic inflammation.