Comparison of Immunoglobulins Status In Splenectomized And Non-Splenectomized Patients With Major Beta-Thalassemia

IF 0.3 Q4 PEDIATRICS Journal of Pediatrics Review Pub Date : 2022-04-01 DOI:10.32598/jpr.10.2.951.2
G. Miri-Aliabad, A. Rezaeifar, Mahdi Salarzaei
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引用次数: 1

Abstract

Background: Thalassemia is one of the most prevalent genetic disorders globally, and infections are one of the major causes of death in these patients. Various studies have attributed the increased susceptibility to bacterial infections in thalassemia patients to changes in their immunological status. Objectives: This research aimed to measure serum levels of immunoglobulins (Igs) in Thalassemia Major (TM) patients and in the control group. Methods: The study included forty TM patients (20 splenectomized and 20 non-splenectomized) and 20 healthy participants (the control group). Three groups were matched for age and gender. Mean serum levels of immunoglobulins (IgG, IgA and IgM) were measured for all individuals by ELISA. P<0.05 was considered the significance level. Results: Increased serum IgG and IgA levels and significantly reduced serum IgM levels were observed in the splenectomized patients compared to the non-splenectomized ones. A comparison of the study groups revealed that serum IgG and IgA levels in the splenectomized patients and the mean serum IgM and IgG levels in the non-splenectomized patients were higher than those of the healthy participants. The mean serum IgM levels in the splenectomized patients and the mean serum IgG levels in the non-splenectomized patients were lower than those of the control group. Conclusions: The results showed that splenectomy could change the immunological status of thalassemia patients. Nevertheless, the exact mechanism for this change was not clear. Studying the serum levels of immunoglobulins might be useful in determining the severity of infections in TM patients.
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严重β地中海贫血脾切除和非脾切除患者免疫球蛋白状态的比较
背景:地中海贫血是全球最常见的遗传疾病之一,感染是这些患者死亡的主要原因之一。各种研究将地中海贫血患者对细菌感染易感性的增加归因于他们免疫状态的变化。目的:本研究旨在测量严重地中海贫血(TM)患者和对照组的血清免疫球蛋白(Igs)水平。方法:本研究包括40例TM患者(20例脾切除术和20例非脾切除术)和20名健康参与者(对照组)。三组按年龄和性别进行匹配。通过ELISA测量所有个体的免疫球蛋白(IgG、IgA和IgM)的平均血清水平。P<0.05为显著性水平。结果:与非脾切除患者相比,脾切除患者的血清IgG和IgA水平升高,血清IgM水平显著降低。研究组的比较显示,脾切除患者的血清IgG和IgA水平以及非脾切除患者中的平均血清IgM和IgG水平高于健康参与者。脾切除患者的平均血清IgM水平和非脾切除患者平均血清IgG水平均低于对照组。结论:脾切除可改变地中海贫血患者的免疫状态。然而,这一变化的确切机制尚不清楚。研究血清免疫球蛋白水平可能有助于确定TM患者感染的严重程度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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审稿时长
8 weeks
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