Elevated serum cholesterol levels are associated with proteinuria over 0.5 g/day in premenopausal women with systemic lupus erythematosus

Haijun Liu, Qianhua Li, Xiu-ning Wei, Jian-da Ma, K. Long, Xia Ouyang, Nemin Liu, Yongsheng Li, L. He, L. Dai, Xiaoyan Cai
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引用次数: 1

Abstract

Background: Systemic lupus erythematosus (SLE) commonly occurs in premenopausal women and is associated with elevated estrogen levels. Patients with SLE may have abnormal serum triglyceride (TG) levels, and lipid reportedly promotes kidney damage in patients with nephrosis. Since estrogen regulates lipid levels, we investigated the serum lipid levels of premenopausal women with SLE and their relationship with proteinuria. Methods: This cross-sectional study included 123 premenopausal women with SLE (SLE group), who were classified into 24-h urine protein exceeding 0.5 g (24 h-UPRO > 0.5 g, n = 22) and 24 h-UPRO ≤ 0.5 g (n = 101) subgroups, and 100 similarly aged healthy women (control group). Clinical characteristics and biomarker levels were compared between these groups. The associated factors of proteinuria over 0.5 g/day were evaluated using multivariate logistic regression. A receiver operating characteristic (ROC) curve was plotted to assess the cholesterol (CH) cut-off associated with increased development of proteinuria over 0.5 g/day. Results: The SLE group had significantly higher serum TG levels than that of control group. 24 h-UPRO were significantly correlated with serum creatinine, CH, TG, and uric acid levels. Serum CH level was the greatest associated factor for proteinuria over 0.5 g/day. The area under the ROC curve was 0.843, with a CH cut-off of 4.58 mmol/L. Patients with serum CH above 4.58 mmol/L had a higher proportion of type IV LN, but with no statistical difference. Conclusions: In premenopausal SLE patients, serum TG levels were higher than in healthy women, and serum CH levels were the primary associated factor for proteinuria over 0.5 g/day. Proteinura over 0.5 g/day may occur in women with SLE with serum CH levels >4.58 mmol/L. CH levels may be useful for predicting proteinuria.
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绝经前系统性红斑狼疮妇女血清胆固醇水平升高与蛋白尿超过0.5 g/天相关
背景:系统性红斑狼疮(SLE)常见于绝经前妇女,与雌激素水平升高有关。SLE患者可能有异常的血清甘油三酯(TG)水平,据报道,脂质会促进肾病患者的肾脏损害。由于雌激素调节脂质水平,我们研究了绝经前SLE妇女的血脂水平及其与蛋白尿的关系。方法:本横断研究纳入123例绝经前SLE女性(SLE组),分为24 h尿蛋白超过0.5 g (24 h-UPRO低于0.5 g, n = 22)和24 h-UPRO≤0.5 g (n = 101)亚组,以及100例年龄相似的健康女性(对照组)。比较两组的临床特征和生物标志物水平。蛋白尿超过0.5 g/d的相关因素采用多因素logistic回归进行评估。绘制受试者工作特征(ROC)曲线,以评估胆固醇(CH)临界值与蛋白尿发生率超过0.5 g/天相关。结果:SLE组血清TG水平明显高于对照组。24 h-UPRO与血清肌酐、CH、TG、尿酸水平显著相关。血清CH水平是蛋白尿超过0.5 g/d的最大相关因素。ROC曲线下面积为0.843,CH截止值为4.58 mmol/L。血清CH > 4.58 mmol/L的患者发生IV型LN的比例较高,但差异无统计学意义。结论:绝经前SLE患者血清TG水平高于健康女性,血清CH水平是蛋白尿超过0.5 g/d的主要相关因素。蛋白尿超过0.5 g/天可能发生在血清CH水平为bb0 4.58 mmol/L的SLE患者。CH水平可用于预测蛋白尿。
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来源期刊
CiteScore
4.00
自引率
0.00%
发文量
88
审稿时长
15 weeks
期刊介绍: International Journal of Immunopathology and Pharmacology is an Open Access peer-reviewed journal publishing original papers describing research in the fields of immunology, pathology and pharmacology. The intention is that the journal should reflect both the experimental and clinical aspects of immunology as well as advances in the understanding of the pathology and pharmacology of the immune system.
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