Maintenance of Vagal Tone with Time-Release Caffeine, But Vagal Withdrawal During Placebo in Caffeine-Habituated Men

IF 1.7 Q4 Pharmacology, Toxicology and Pharmaceutics Journal of Caffeine and Adenosine Research Pub Date : 2018-06-01 DOI:10.1089/CAFF.2017.0039

Michael B. La Monica, D. Fukuda, Ran Wang, Adam M. Gonzalez, Adam J. Wells, J. Hoffman, Jeffrey R Stout

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引用次数: 3

Abstract

Objective: This study aimed to determine the effects of a time-release caffeine (TR-CAF) supplement and caffeine abstinence on heart rate variability (HRV) in habitual users. Methods: Ten caffeine-habituated (>200 mg per day) men (25.9 ± 3.2 years; 1.81 ± 0.08 m; and 92.9 ± 9.9 kg) performed three trials, each separated by 1 week. During each trial, participants randomly consumed either 194 mg of caffeine in a multi-ingredient supplement containing TR-CAF; an instant-release caffeine supplement (CAF); or placebo (PL). HRV was assessed for 10 minutes in the supine position at baseline (BL), and every hour after supplementation for 8 hours. Time-domain [average heart rate, mean standard deviation of all normal-to-normal (NN) intervals (SDNN), and root mean square of differences between adjacent NN intervals (RMSSD)] and frequency-domain [low frequency (LF), high frequency (HF), total power (TP), LF/HF, and an index of parasympathetic nervous system (PNS = HF/TP)] measures were recorded. A two-way (trial × t...

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缓释咖啡因维持迷走神经张力，但在咖啡因习惯的男性安慰剂期间迷走神经戒断

目的：本研究旨在确定定时释放咖啡因（TR-CAF）补充剂和咖啡因戒断对习惯性使用者心率变异性（HRV）的影响。方法：10种咖啡因习惯（>200 毫克/天）男性（25.9 ± 3.2年；1.81 ± 0.08 m；和92.9 ± 9.9 kg）进行了三次试验，每次间隔1周。在每次试验中，参与者随机消费194 mg在含有TR-CAF的多成分补充剂中的咖啡因；即时释放咖啡因补充剂（CAF）；或安慰剂（PL）。在基线（BL）仰卧位评估HRV 10分钟，并在补充8小时后每小时评估一次。时域[平均心率、所有正常到正常（NN）间期的平均标准差（SDNN）和相邻NN间期之间的差均方根（RMSSD）]和频域[低频（LF）、高频（HF）、总功率（TP）、LF/HF和副交感神经系统指数（PNS） = HF/TP）]测量。双向（试验 × t。。。

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Journal of Caffeine and Adenosine Research Multiple-

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