Evaluation of cardiac electromechanics in patients with newly diagnosed hypertension.

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-12-01 Epub Date: 2023-08-03 DOI:10.1097/MBP.0000000000000667

Timor Omar, Şerif Hamideyin, Muammer Karakayali, İnanç Artaç, Yavuz Karabağ, Cihan Dündar, İbrahim Rencüzoğullari

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Abstract

Objectives: This study aimed to investigate the relationship between subclinical left ventricular (LV) systolic dysfunction and ECG parameters in newly diagnosed hypertension patients.

Methods: In this cross-sectional study, adults diagnosed with hypertension based on 24-h ambulatory blood pressure monitor recordings were included. The patients were classified into two groups based on the presence of subclinical LV systolic dysfunction according to LV global longitudinal strain (LVGLS). Findings were compared between the two groups.

Results: A total of 244 patients (female, 55.7%) were included. Based on LVGLS, 82 (33.6%) patients had subclinical LV systolic dysfunction. The proportion of early repolarization pattern (ERP) on ECG was significantly higher in patients with subclinical LV systolic dysfunction than in patients with normal LV systolic function [24 (28.6%) vs. 8 (5%), P < 0.001]. PR and corrected QT intervals were also significantly longer in patients with subclinical LV systolic dysfunction than in patients with normal LV systolic function [median (interquartile range), 148 (132-158) vs. 141 (127-152), P = 0.036 and 443 (427-459) vs. 431 (411-455), P = 0.007, respectively]. According to multivariate regression analysis ERP, early (E) wave velocity/late (A) wave velocity (E/A), and LV mass index were independently associated with subclinical LV systolic dysfunction.

Conclusion: In newly diagnosed hypertension patients, the ERP on admission ECG could be a sign of subclinical systolic dysfunction.

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新诊断高血压患者的心脏生物力学评价

本研究旨在探讨新诊断高血压患者亚临床左心室收缩功能障碍与心电图参数之间的关系。在这项横断面研究中，纳入了根据24小时动态血压监测记录诊断为高血压的成年人。根据左心室整体纵向应变（LVGLS），根据亚临床左心室收缩功能障碍的存在将患者分为两组。比较两组的研究结果。共纳入244名患者（女性，55.7%）。根据LVGLS，82名（33.6%）患者存在亚临床左心室收缩功能障碍。亚临床左心室收缩功能障碍患者心电图上早期复极模式（ERP）的比例显著高于左心室收缩功能正常的患者[24（28.6%）vs.8（5%），P < 亚临床左心室收缩功能障碍患者的PR和校正QT间期也明显长于左心室收缩功能正常患者[中位数（四分位间距），148（132-158）vs.141（127-152），P = 0.036和443（427–459）对431（411–455），P = 0.007）。根据多元回归分析ERP，早期（E）波速度/晚期（A）波速度（E/A）和左心室质量指数与亚临床左心室收缩功能障碍独立相关。在新诊断的高血压患者中，入院心电图上的ERP可能是亚临床收缩功能障碍的标志。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.