Preparation of Eumelanin-Encapsulated Stereocomplex Polylactide Nano/Microparticles for Degradable Biocompatible UV-Shielding Products

IF 3.1 3区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Nanomaterials and Nanotechnology Pub Date : 2023-08-08 DOI:10.1155/2023/9832904
O. Putri, A. Petchsuk, Suthawan Buchatip, W. Supmak, C. Kaewsaneha, K. Thananukul, Bunthoeun Nim, S. Bayram, K. Thumanu, P. Opaprakasit
{"title":"Preparation of Eumelanin-Encapsulated Stereocomplex Polylactide Nano/Microparticles for Degradable Biocompatible UV-Shielding Products","authors":"O. Putri, A. Petchsuk, Suthawan Buchatip, W. Supmak, C. Kaewsaneha, K. Thananukul, Bunthoeun Nim, S. Bayram, K. Thumanu, P. Opaprakasit","doi":"10.1155/2023/9832904","DOIUrl":null,"url":null,"abstract":"The role of eumelanin as a natural pigment in protecting human skin from ultraviolet (UV) light has drawn vast interest in the research and industrial community. Encapsulation of the compound by various shell materials has been extensively studied to optimize and prolong its shielding efficiency from UV penetration through the skin. Polylactide (PLA)-based copolymers have been widely used in the encapsulation of various active compounds due to their biocompatibility and biodegradability that facilitate sustained release of the active compounds. In this work, stereocomplex PLA (sc-PLA) derived from mixtures of poly(D-lactide-caprolactone-D-lactide), P(DLA-b-CL-b-DLA), a triblock copolymer with linear poly(L-lactide), and PLLA are employed to encapsulate eumelanin by an oil-in-water emulsion (O/W) technique. The effect of eumelanin distribution in PLA’s enantiomers and ultrasonication on the physicochemical properties, encapsulation efficiency, and release behavior of the nano/microparticles were evaluated. The potential application of the resulting particles for sunscreen products was assessed in terms of UV absorbance and in vitro sun protection factor (SPF). The nano/microparticles show a hollow spherical structure, whose size can be controlled by ultrasonication. The distribution of eumelanin and the ultrasonication process play a key role in the growth of sc-PLA and the crystalline structure of the particles. The highest encapsulation efficiency of 46.6% was achieved for sc-PLA2U particles. The high content of eumelanin and the hollow structure with a large surface area lead to improvement in the UV absorbance and sunscreen performance of the particles, as revealed by the increase in the SPF value from 9.7 to 16.5. The materials show high potential for various applications, especially in cosmetic and pharmaceutical fields, as UV-shielding products.","PeriodicalId":19018,"journal":{"name":"Nanomaterials and Nanotechnology","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomaterials and Nanotechnology","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1155/2023/9832904","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

The role of eumelanin as a natural pigment in protecting human skin from ultraviolet (UV) light has drawn vast interest in the research and industrial community. Encapsulation of the compound by various shell materials has been extensively studied to optimize and prolong its shielding efficiency from UV penetration through the skin. Polylactide (PLA)-based copolymers have been widely used in the encapsulation of various active compounds due to their biocompatibility and biodegradability that facilitate sustained release of the active compounds. In this work, stereocomplex PLA (sc-PLA) derived from mixtures of poly(D-lactide-caprolactone-D-lactide), P(DLA-b-CL-b-DLA), a triblock copolymer with linear poly(L-lactide), and PLLA are employed to encapsulate eumelanin by an oil-in-water emulsion (O/W) technique. The effect of eumelanin distribution in PLA’s enantiomers and ultrasonication on the physicochemical properties, encapsulation efficiency, and release behavior of the nano/microparticles were evaluated. The potential application of the resulting particles for sunscreen products was assessed in terms of UV absorbance and in vitro sun protection factor (SPF). The nano/microparticles show a hollow spherical structure, whose size can be controlled by ultrasonication. The distribution of eumelanin and the ultrasonication process play a key role in the growth of sc-PLA and the crystalline structure of the particles. The highest encapsulation efficiency of 46.6% was achieved for sc-PLA2U particles. The high content of eumelanin and the hollow structure with a large surface area lead to improvement in the UV absorbance and sunscreen performance of the particles, as revealed by the increase in the SPF value from 9.7 to 16.5. The materials show high potential for various applications, especially in cosmetic and pharmaceutical fields, as UV-shielding products.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
真黑素包封立体配合物聚乳酸纳米/微粒的制备及其生物相容性紫外线屏蔽产品
真黑色素作为一种天然色素,在保护人类皮肤免受紫外线照射方面的作用引起了研究和工业界的广泛兴趣。通过各种外壳材料对该化合物的封装已经进行了广泛的研究,以优化和延长其对紫外线穿透皮肤的屏蔽效率。聚乳酸(PLA)基共聚物由于其生物相容性和生物降解性促进了活性化合物的持续释放,已被广泛用于各种活性化合物的封装。在本工作中,采用水包油乳液(O/W)技术,利用由聚(D-丙交酯-己内酯-D-丙交酯)、P(DLA-b-CL-b-DLA)、线性聚(L-丙交酯的三嵌段共聚物和PLLA的混合物衍生的立体复合物PLA(sc-PLA)包封真黑色素。评价了真黑色素在PLA对映体中的分布和超声处理对纳米/微米颗粒的物理化学性质、包封效率和释放行为的影响。根据紫外线吸收率和体外防晒系数(SPF)评估了所得颗粒在防晒产品中的潜在应用。纳米/微米颗粒显示出中空的球形结构,其尺寸可以通过超声控制。真黑色素的分布和超声处理过程对sc-PLA的生长和颗粒的晶体结构起着关键作用。sc-PLA2U颗粒的包封效率最高,达到46.6%。高含量的真黑色素和具有大表面积的中空结构导致颗粒的紫外线吸收和防晒性能的改善,如SPF值从9.7增加到16.5所示。这些材料在各种应用中显示出很高的潜力,特别是在化妆品和制药领域,作为紫外线屏蔽产品。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Nanomaterials and Nanotechnology
Nanomaterials and Nanotechnology NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY
CiteScore
7.20
自引率
21.60%
发文量
13
审稿时长
15 weeks
期刊介绍: Nanomaterials and Nanotechnology is a JCR ranked, peer-reviewed open access journal addressed to a cross-disciplinary readership including scientists, researchers and professionals in both academia and industry with an interest in nanoscience and nanotechnology. The scope comprises (but is not limited to) the fundamental aspects and applications of nanoscience and nanotechnology
期刊最新文献
Grewia tenax-Mediated Silver Nanoparticles as Efficient Antibacterial and Antifungal Agents Material Removal Mechanism and Evolution of Subsurface Defects during Nanocutting of Monocrystalline Cu Rapid Colorimetric Detection of Hg (II) Based on Hg (II)-Induced Suppressed Enzyme-Like Reduction of 4-Nitrophenol by Au@ZnO/Fe3O4 in a Cosmetic Skin Product Nanomaterials in Nanophotonics Structure for Performing All-Optical 2 × 1 Multiplexer Based on Elliptical IMI-Plasmonic Waveguides Low Dimension Elemental and van der Waals Hetetostructures Materials including C Nanostructures and Perovskites
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1