K. C. Sekhar, Rajanikanth A. Rajanikanth, Md Nazneen Bobby, J. R. Kanala
{"title":"Anticancer potential of D-limonene and hispolon against colon cancer cell lines","authors":"K. C. Sekhar, Rajanikanth A. Rajanikanth, Md Nazneen Bobby, J. R. Kanala","doi":"10.5530/CTBP.2020.3.31","DOIUrl":null,"url":null,"abstract":"Natural products and associated combination therapy have gained prominent role in decreasing the adverse effects of synthetic drugs engaged in the severity of colon cancer. DLimonene a dietary monoterpene and hispolon a bioactive polyphenol proven to be anticancer agents independently against several cancers. The current study is designed to examine complimentary anticancer effect of D-limonenehispolonconcoction in COLO-205 and HCT-116 cell lines. Collectively, our cell viability, cell migration, clonogenic tests and CompuSyn analysis results exemplified that the combination of D-limonene and hispolonnatural products eminently effective against colon cancer cell lines.Gastric cancer patients are reported to develop severe side effects due to the currently available chemotherapy,our combinational anticancer therapy bydietary natural compounds would be highly beneficial to the patients.","PeriodicalId":10980,"journal":{"name":"Current Trends in Biotechnology and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Trends in Biotechnology and Pharmacy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5530/CTBP.2020.3.31","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 1
Abstract
Natural products and associated combination therapy have gained prominent role in decreasing the adverse effects of synthetic drugs engaged in the severity of colon cancer. DLimonene a dietary monoterpene and hispolon a bioactive polyphenol proven to be anticancer agents independently against several cancers. The current study is designed to examine complimentary anticancer effect of D-limonenehispolonconcoction in COLO-205 and HCT-116 cell lines. Collectively, our cell viability, cell migration, clonogenic tests and CompuSyn analysis results exemplified that the combination of D-limonene and hispolonnatural products eminently effective against colon cancer cell lines.Gastric cancer patients are reported to develop severe side effects due to the currently available chemotherapy,our combinational anticancer therapy bydietary natural compounds would be highly beneficial to the patients.
期刊介绍：
The Association of Biotechnology and Pharmacy (ABAP) will be useful to form a forum for scientists so that they can bring together to discuss and find scientific solutions to the problems of society. The annual meetings will help the members to share their knowledge and publish their research knowledge particularly by members and fellows of the Association and special care will be taken to provide an opportunity for young scientists. Besides this the association is planned to organize symposia, seminars and workshops on current developments of Biotechnology and Pharmacy particularly on the subject of current scientific interest, and the proceedings of which will be published regularly. And in view of the vast development of science and to disseminate the problems in publication of research work, an international journal of Current Trends in Biotechnology and Pharmacy has been started by ABAP.
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