Coffee and Green Tea Decoction Intake in the Tunisian Population According to Genetic Polymorphisms of Genes Involved in Habitual Caffeine Intake

IF 0.1 4区生物学 Q4 GENETICS & HEREDITY International Journal of Human Genetics Pub Date : 2020-10-25 DOI:10.31901/24566330.2020/20.04.765

S. Denden

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Abstract

ABSTRACT The relationship between genetic variation and caffeinated beverages intake has been investigated in various human populations, but not among North Africans who have distinct caffeinated beverage dietary habits. Therefore, this study analysed the association between rs6968865 (AHR), rs382140 (NRCAM), rs9526558 (CAB39L), rs7754744 (PDSS2) and rs68157013 (TAS2R43) SNPs from previous GWASs on habitual caffeine consumption and caffeinated beverage intake in 568 healthy blood donors from the Tunisian population. The AHR caffeine metabolism gene SNP was associated with coffee intake but not with green tea decoction. However, the association of SNPs with caffeine metabolism (CAB39L and PDSS2), addiction to caffeine (NRCAM) and perceived caffeine bitterness (TAS2R43) genes was only observed or was stronger with the highest caffeine-containing beverage green tea decoction. The researchers further detected an opposite association of PDSS2 gene SNP with coffee and tea intake. The study provides additional data on caffeinated beverage intake genetics in a population with specific dietary habits

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突尼斯人群咖啡和绿茶汤摄入与习惯性咖啡因摄入相关基因的遗传多态性

摘要基因变异与含咖啡因饮料摄入之间的关系已经在不同的人群中进行了研究，但在有不同含咖啡因饮料饮食习惯的北非人中却没有。因此，本研究分析了来自突尼斯568名健康献血者的既往GWAS的rs6968865（AHR）、rs382140（NRCAM）、rs9526558（CAB39L）、rs7754744（PDSS2）和rs68157013（TAS2R43）SNPs与习惯性咖啡因摄入和含咖啡因饮料摄入之间的关系。AHR咖啡因代谢基因SNP与咖啡摄入量有关，但与绿茶汤剂无关。然而，SNPs与咖啡因代谢（CAB39L和PDSS2）、咖啡因成瘾（NRCAM）和感知咖啡因苦味（TAS2R43）基因的相关性仅在含咖啡因最高的饮料绿茶汤中观察到或更强。研究人员进一步检测到PDSS2基因SNP与咖啡和茶的摄入存在相反的关联。这项研究提供了关于特定饮食习惯人群中含咖啡因饮料摄入遗传学的额外数据

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International Journal of Human Genetics GENETICS & HEREDITY-

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