Elevated ambulatory systolic-diastolic pressure regression index is genetically determined in hypertensive patients with coronary heart disease

IF 2.3 4区医学 Q2 PERIPHERAL VASCULAR DISEASE Blood Pressure Pub Date : 2017-01-16 DOI:10.1080/08037051.2016.1273741

M. Wirtwein, O. Melander, M. Sjőgren, M. Hoffmann, K. Narkiewicz, M. Gruchała, W. Sobiczewski

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引用次数: 3

Abstract

Abstract Objectives: Ambulatory systolic-diastolic pressure regression index (ASDPRI) as a composite marker of cardiovascular (CV) properties is related to CV complications. However, genetic determinants of ASDPRI are not known. The aim of this study is to report the relationship between certain single nucleotide polymorphisms (SNP) and ASDPRI in hypertensive patients with CAD confirmed by coronary angiography. Methods: A total of 1345 hypertensive subjects with CAD were included. SNPs were selected from genome-wide association studies. SNPs were reported to be associated with coronary artery disease risk. There were significant differences in 24 h and daytime and nighttime ASDPRIs for PHCTR1, LPA and ADAMTS7 polymorphisms. Genetic risk score (GRS18) was constructed to evaluate additive effect of 18 SNPs for ASDPRI. Results: Analysis of covariance revealed a significant relationship between the PPAB2B (β − 0.85; 95 CI −1.85–−0.16, p < 0.02), WDR12 (β − 1.31; 95 CI −2.19–−0.43, p < 0.01) polymorphisms and nighttime ASDPRI dipping. Analysis of covariance revealed a significant relationship between GRS 18 and 24-h ASDPRI (β 0.34; 95 CI 0.16–0.31, p < 0.01). Conclusions: In conclusion, ADAMTS7 and LPA polymorphisms are related to 24-h ASDPRI but PPAB2B and WDR12 gene polymorphisms are associated with nighttime ASDPRI dipping. A total of 24-h ASDPRI is determined by GRS18.

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高血压合并冠心病患者的动态收缩压-舒张压回归指数升高是遗传决定的

摘要目的：动态收缩-舒张压回归指数（ASDPRI）作为心血管（CV）特性的复合标志物，与心血管并发症有关。然而，ASDPRI的遗传决定因素尚不清楚。本研究的目的是报道某些单核苷酸多态性（SNP）与冠状动脉造影证实的高血压CAD患者的ASDPRI之间的关系。方法：纳入1345例高血压合并冠心病患者。SNPs选自全基因组关联研究。据报道，SNPs与冠状动脉疾病风险相关。24 h以及PHCTR1、LPA和ADAMTS7多态性的日间和夜间ASDPRI。构建遗传风险评分（GRS18）来评估18个SNPs对ASDPRI的加性效应。结果：协方差分析显示PPAB2B（ − 0.85；95 CI−1.85–−0.16，p < 0.02），WDR12（β − 1.31；95 CI−2.19–−0.43，p < 0.01）多态性和夜间ASDPRI下降。协方差分析显示GRS18和24小时ASDPRI之间存在显著关系（β0.34；95 CI 0.16–0.31，p < 结论：ADAMTS7和LPA多态性与24小时ASDPRI有关，而PPAB2B和WDR12基因多态性与夜间ASDPRI下降有关。总共24小时的ASDPRI由GRS18确定。

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来源期刊

Blood Pressure 医学-外周血管病

CiteScore

3.00

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： For outstanding coverage of the latest advances in hypertension research, turn to Blood Pressure, a primary source for authoritative and timely information on all aspects of hypertension research and management. Features include: • Physiology and pathophysiology of blood pressure regulation • Primary and secondary hypertension • Cerebrovascular and cardiovascular complications of hypertension • Detection, treatment and follow-up of hypertension • Non pharmacological and pharmacological management • Large outcome trials in hypertension.