How do histopathologIcal fIndIngs affect cervical lymph metastasis in laryngeal cancer? A RETROSPECTIVE STUDY AND LITERATURE REVIEW

IF 0.2 Q4 OTORHINOLARYNGOLOGY ENT Updates Pub Date : 2019-03-19 DOI:10.32448/ENTUPDATES.536842
Ş. Belli, M. Yıldırım, F. Kaya, Tolga Bilece, M. Oktay
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Abstract

Purpose:  This study aimed to elucidate how histopathological findings relate to the existence of metastases in lymph nodes in a cohort of surgical cases with squamous cell carcinoma of the larynx. Material and Methods:  A cohort of cases from the ENT department, who had partial or total laryngectomy and dissection of the neck in the period spanning January 2008 to June 2017 were evaluated retrospectively. 150 cases were deemed appropriate for inclusion in the study. The histopathological notes and clinical findings of these cases were compared to each other.  Findings:  The glottic group had lower levels of lymphovascular invasion (p<0.05). Tumours staged at T3 or T4 level or endophytic in subtype were, however, more likely to have lymphovascular invasive features (p<0.05). For neoplasms with a high degree of differentiation, it was less frequent to observe invasion of lymphatics, metastasis to the cervical nodes or invasion beyond the capsule (p<0.05). Perineural invasion was not associated with a greater risk of the neoplasm metastasizing to the cervical lymphovasculature, but invasion of the lymphatics did signal an increase in metastasis (p<0.05). Conclusion: Cervical lymphatic metastasis of squamous cell carcinoma of the larynx has a high degree of correlation with histopathological grading.
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组织病理学结果如何影响喉癌颈部淋巴转移?回顾性研究及文献综述
目的:本研究旨在阐明喉部鳞状细胞癌手术患者的淋巴结转移与组织病理学的关系。材料和方法:回顾性评估2008年1月至2017年6月期间耳鼻喉科部分或全部喉切除术和颈部夹层的病例队列。150个病例被认为适合纳入研究。将这些病例的组织病理学记录和临床表现进行比较。结果:声门组淋巴血管侵犯水平较低(p<0.05)。然而,T3或T4分期或亚型内生肿瘤更容易出现淋巴血管浸润特征(p<0.05)。在分化程度高的肿瘤中,淋巴浸润、宫颈淋巴结转移、囊外浸润的发生率较低(p<0.05)。神经周围浸润与肿瘤转移到颈部淋巴血管的风险无关,但淋巴浸润确实表明转移增加(p<0.05)。结论:喉部鳞状细胞癌颈部淋巴转移与组织病理学分级高度相关。
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来源期刊
ENT Updates
ENT Updates OTORHINOLARYNGOLOGY-
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