Durvalumab for the treatment of PD-L1 non-small cell lung cancer

T. Naito, H. Shiraishi, Y. Fujiwara
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引用次数: 1

Abstract

ABSTRACT Introduction: Immune checkpoint inhibitors, monoclonal antibodies directed against programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1), have broadened treatment options for patients with non-small cell lung cancer (NSCLC). Durvalumab is a selective, high-affinity, human IgG1 monoclonal anti-PD-L1 antibody that blocks interactions of PD-L1 with PD-1 and CD80. Areas covered: We reviewed clinical data supporting the use of durvalumab as a monotherapy and combination therapy for the treatment of locally advanced and advanced NSCLC. Expert commentary: Durvalumab as a monotherapy or combination therapy has shown well-tolerated safety profiles for NSCLC in several trials. Durvalumab monotherapy in advanced NSCLC patients with PD-L1 ≥ 25% as later line (ATLANTIC study) therapy led to clinically meaningful improvements compared to standard of care. Combination therapy comprising durvalumab plus tremelimumab for advanced NSCLC did not show clinical efficacy in three phase III trials. Durvalumab administered after chemoradiotherapy in stage III NSCLC (PACIFIC study) significantly improved progression-free survival and overall survival. This result has led to approval of durvalumab for patients with locally advanced NSCLC as the standard of care. Ongoing trials provide insight into how durvalumab fits into the rapidly evolving therapeutic landscape for locally advanced or advanced NSCLC.
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杜伐单抗治疗PD-L1非小细胞肺癌癌症
免疫检查点抑制剂是一种针对程序性死亡1 (PD-1)/程序性死亡配体1 (PD-L1)的单克隆抗体,它拓宽了非小细胞肺癌(NSCLC)患者的治疗选择。Durvalumab是一种选择性、高亲和力的人IgG1单克隆抗PD-L1抗体,可阻断PD-L1与PD-1和CD80的相互作用。涵盖领域:我们回顾了支持使用durvalumab作为局部晚期和晚期NSCLC的单药和联合治疗的临床数据。专家评论:Durvalumab作为单一疗法或联合疗法在一些试验中显示出NSCLC耐受性良好的安全性。与标准治疗相比,Durvalumab单药治疗PD-L1≥25%的晚期NSCLC患者作为后期线(ATLANTIC研究)治疗导致临床有意义的改善。durvalumab + tremelimumab联合治疗晚期NSCLC在三个III期试验中没有显示出临床疗效。在III期NSCLC (PACIFIC研究)放化疗后给予Durvalumab可显著改善无进展生存期和总生存期。这一结果使得durvalumab被批准用于局部晚期NSCLC患者作为标准治疗。正在进行的试验为durvalumab如何适应局部晚期或晚期NSCLC快速发展的治疗前景提供了见解。
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来源期刊
CiteScore
2.30
自引率
0.00%
发文量
9
期刊介绍: Expert Review of Precision Medicine and Drug Development publishes primarily review articles covering the development and clinical application of medicine to be used in a personalized therapy setting; in addition, the journal also publishes original research and commentary-style articles. In an era where medicine is recognizing that a one-size-fits-all approach is not always appropriate, it has become necessary to identify patients responsive to treatments and treat patient populations using a tailored approach. Areas covered include: Development and application of drugs targeted to specific genotypes and populations, as well as advanced diagnostic technologies and significant biomarkers that aid in this. Clinical trials and case studies within personalized therapy and drug development. Screening, prediction and prevention of disease, prediction of adverse events, treatment monitoring, effects of metabolomics and microbiomics on treatment. Secondary population research, genome-wide association studies, disease–gene association studies, personal genome technologies. Ethical and cost–benefit issues, the impact to healthcare and business infrastructure, and regulatory issues.
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