Virgi Mayang Maharani, Ken Wirastuti, Meyvita Silviana, Naili Sofi Riasari
{"title":"Ambroxol therapy for Parkinson’s disease: Systematic literature review","authors":"Virgi Mayang Maharani, Ken Wirastuti, Meyvita Silviana, Naili Sofi Riasari","doi":"10.37897/rjn.2023.2.1","DOIUrl":null,"url":null,"abstract":"Parkinson’s disease (PD) is the second most common neurodegenerative disease. The accumulation of α-synuclein protein in the basal ganglia is the underlying pathogenesis of PD. Genetic abnormalities are one of the predisposing factors for PD. PDs with GBA gene mutations have abnormalities coding for β-glucocerebrosidase (GCase) enzymes in lysosomes, which lead to increased accumulation of α-synuclein. Ambroxol has long been known as a therapy for airway disorders which also has antioxidant benefits. However, recently, there have been many experimental studies examining the benefits of ambroxol in neurodegenerative diseases, including PD. This study aims to examine experimental studies of ambroxol administration in PD.","PeriodicalId":37662,"journal":{"name":"Romanian Journal of Neurology/ Revista Romana de Neurologie","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Romanian Journal of Neurology/ Revista Romana de Neurologie","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37897/rjn.2023.2.1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Parkinson’s disease (PD) is the second most common neurodegenerative disease. The accumulation of α-synuclein protein in the basal ganglia is the underlying pathogenesis of PD. Genetic abnormalities are one of the predisposing factors for PD. PDs with GBA gene mutations have abnormalities coding for β-glucocerebrosidase (GCase) enzymes in lysosomes, which lead to increased accumulation of α-synuclein. Ambroxol has long been known as a therapy for airway disorders which also has antioxidant benefits. However, recently, there have been many experimental studies examining the benefits of ambroxol in neurodegenerative diseases, including PD. This study aims to examine experimental studies of ambroxol administration in PD.
期刊介绍：
ROMANIAN JOURNAL OF NEUROLOGY (Revista Română de Neurologie), the official journal of the Romanian Society of Neurology, was founded in 2001, being a prestigious scientific journal that provides a high quality in terms of scientific content, but also the editorial and graphic aspect, both through an impartial process of selection, evaluation and correction of articles (peer review procedure), as well as providing editorial, graphic and printing conditions at the highest level. In order to increase the scientific standards of the journal, special attention was paid to the improvement of the quality of the published materials. Guidance articles, clinical trials and case studies are structured in several sections: reviews, original articles, case reports, images in neurology. All articles are published entirely in English. A team of reputable medical professionals in the field of neurology is involved in a rigorous peer review process that complies with international ethics and quality rules in the academic world.
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