Importance of radiobiological studies for the advancement of boron neutron capture therapy (BNCT)

IF 4.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Expert Reviews in Molecular Medicine Pub Date : 2022-03-31 DOI:10.1017/erm.2022.7
A. Monti Hughes
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引用次数: 12

Abstract

Abstract Boron neutron capture therapy (BNCT) is a tumour selective particle radiotherapy, based on the administration of boron carriers incorporated preferentially by tumour cells, followed by irradiation with a thermal or epithermal neutron beam. BNCT clinical results to date show therapeutic efficacy, associated with an improvement in patient quality of life and prolonged survival. Translational research in adequate experimental models is necessary to optimise BNCT for different pathologies. This review recapitulates some examples of BNCT radiobiological studies for different pathologies and clinical scenarios, strategies to optimise boron targeting, enhance BNCT therapeutic effect and minimise radiotoxicity. It also describes the radiobiological mechanisms induced by BNCT, and the importance of the detection of biomarkers to monitor and predict the therapeutic efficacy and toxicity of BNCT alone or combined with other strategies. Besides, there is a brief comment on the introduction of accelerator-based neutron sources in BNCT. These sources would expand the clinical BNCT services to more patients, and would help to make BNCT a standard treatment modality for various types of cancer. Radiobiological BNCT studies have been of utmost importance to make progress in BNCT, being essential to design novel, safe and effective clinical BNCT protocols.
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放射生物学研究对推进硼中子俘获治疗的重要性
硼中子俘获疗法(BNCT)是一种肿瘤选择性粒子放射治疗,其基础是给予肿瘤细胞优先结合的硼载体,然后用热中子或超热中子束照射。迄今为止,BNCT的临床结果显示了治疗效果,与患者生活质量的改善和生存期的延长有关。在适当的实验模型的转化研究是必要的,以优化不同病理的BNCT。本文综述了不同病理和临床情况下BNCT放射生物学研究的一些例子,以及优化硼靶向,提高BNCT治疗效果和减少放射毒性的策略。本文还介绍了BNCT诱导的放射生物学机制,以及检测生物标志物对监测和预测BNCT单独或联合其他策略的治疗效果和毒性的重要性。此外,还对BNCT中基于加速器的中子源的引入作了简要评述。这些资源将使临床BNCT服务扩展到更多的患者,并有助于使BNCT成为各种类型癌症的标准治疗方式。放射生物学BNCT研究对于BNCT的发展至关重要,对于设计新颖、安全、有效的临床BNCT方案至关重要。
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来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
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