Evaluation of Serum CTNNβ1 and E-cadherin Levels in Hepatitis Patients

Abstract

ÖZ were 44.57±29.61 ng/mL in the control group, and 42.76±23.23, 45.72±27.33 and 71.02±31.03 ng/mL in HBV-DNA-1, 2 and 3 groups, respectively. In addition, E-cadherin values were statistically significant in the HBV-DNA-3 group compared to other groups (p=0.001; p<0.01). The values of β-catenin were 0.75±0.47 ng/mL in the control group and were 1.05±0.63, 0.93±0.4 and 1.58±1.94 ng/mL in the DNA-1, 2, and 3 groups, respectively. The β-catenin value in the control group was found to be statistically significant compared to hepatitis B groups (p=0.001; p<0.01). Conclusion: E-cadherin values were found to be significantly lower in the HBV-DNA-1 group with the highest viral load. There may be a loss of E-cadherin due to severe inflammation in this group. Monitoring the levels of β-catenin and E-cadherin may be important for evaluating the possible risk and prognosis for liver carcinoma in these patients.