KV Kolomiets, IV Isaev, VV Kovalev, NV Grishchenko, DI Kokovihina, AA Morozova, AR Torosyan, VV Shashkova, PV Snegireva
{"title":"Multidisciplinary approach to treatment of a patient with unresectable metastatic liver lesion spawned by HER2+ gastric adenocarcinoma giving","authors":"KV Kolomiets, IV Isaev, VV Kovalev, NV Grishchenko, DI Kokovihina, AA Morozova, AR Torosyan, VV Shashkova, PV Snegireva","doi":"10.24075/brsmu.2023.031","DOIUrl":null,"url":null,"abstract":"In 85% of patients worldwide, gastric cancer (GC) metastasizes from the very beginning or within three years. In 30–50% of cases, metastases, both synchronous and metachronous, grow into liver. Multifocal liver metastases translate into an unfavorable prognosis: the median survival period is 10–15 months, with less than 10% of the patients surviving past three years. In such cases, the palliative treatment option is systemic chemotherapy. Combined with immunotherapy, transarterial chemoembolization (TACE), a relatively new method of local treatment of metastatic foci, offer new options of combating liver metastases. This work presents a clinical case of application of this combination coupled with chemotherapy to treat a patient with unresectable liver metastases spawned by HER2+ gastric adenocarcinoma. From the day of diagnosis, the patient's life expectancy was 42 months.","PeriodicalId":9344,"journal":{"name":"Bulletin of Russian State Medical University","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Russian State Medical University","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24075/brsmu.2023.031","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
In 85% of patients worldwide, gastric cancer (GC) metastasizes from the very beginning or within three years. In 30–50% of cases, metastases, both synchronous and metachronous, grow into liver. Multifocal liver metastases translate into an unfavorable prognosis: the median survival period is 10–15 months, with less than 10% of the patients surviving past three years. In such cases, the palliative treatment option is systemic chemotherapy. Combined with immunotherapy, transarterial chemoembolization (TACE), a relatively new method of local treatment of metastatic foci, offer new options of combating liver metastases. This work presents a clinical case of application of this combination coupled with chemotherapy to treat a patient with unresectable liver metastases spawned by HER2+ gastric adenocarcinoma. From the day of diagnosis, the patient's life expectancy was 42 months.
期刊介绍：
Bulletin of Russian State Medical University (Bulletin of RSMU, ISSN Print 2500–1094, ISSN Online 2542–1204) is a peer-reviewed medical journal of Pirogov Russian National Research Medical University (Moscow, Russia). The original language of the journal is Russian (Vestnik Rossiyskogo Gosudarstvennogo Meditsinskogo Universiteta, Vestnik RGMU, ISSN Print 2070–7320, ISSN Online 2070–7339). Founded in 1994, it is issued once every two months publishing articles on clinical medicine and medical and biological sciences, first of all oncology, neurobiology, allergy and immunology, medical genetics, medical microbiology and infectious diseases. Every issue is thematic. Deadlines for manuscript submission are announced in advance. The number of publications on topics in spite of the issue topic is limited. The journal accepts only original articles submitted by their authors, including articles that present methods and techniques, clinical cases and opinions. Authors must guarantee that their work has not been previously published elsewhere in whole or in part and in other languages and is not under consideration by another scientific journal. The journal publishes only one review per issue; the review is ordered by the editors.
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