Reduced Dose Intravesical Bacillus Calmette-Guérin: Why It Might Not Matter.

IF 17.7 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-06-03 eCollection Date: 2022-01-01 DOI:10.3233/BLC-211648
Ashish M Kamat, Niyati Lobo, Seth P Lerner, Roger Li, Justin T Matulay, Joan Palou, J Alfred Witjes, Morgan Rouprêt, Angela B Smith, Sam S Chang, Neal D Shore, Gary D Steinberg, Colin P Dinney, Robert S Svatek, Donald L Lamm
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Abstract

When it comes to the treatment of patients with non-muscle-invasive bladder cancer (NMIBC) with intravesical bacillus Calmette-Guérin (BCG), two questions must be considered: 1) what dose to give, and 2) for how long? The issue of optimal dose and duration has been the subject of several randomized trials and is especially pertinent in the context of a global BCG shortage. Despite this, there appears to be uncertainty as to whether BCG dose or duration may be compromised in the event of shortage. As such, we wish to summarize the available evidence as an aid to the practicing urologist.

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小剂量膀胱内注射Calmette Guérin芽孢杆菌:为什么它可能无关紧要
当使用膀胱内卡介苗(BCG)治疗非肌肉浸润性膀胱癌(NMIBC)患者时,必须考虑两个问题:1)给多少剂量,2)多长时间?最佳剂量和持续时间的问题一直是几个随机试验的主题,在全球卡介苗短缺的背景下尤其相关。尽管如此,在卡介苗短缺的情况下,卡介苗的剂量或持续时间是否会受到影响似乎还不确定。因此,我们希望总结现有的证据,以帮助执业泌尿科医生。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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