Opioid Dispensing Practices in the Acute Care Setting: A Retrospective Study

Mohamad Moussa, Lekha Vemuru, Robert Dohar, D. Lubarsky, S. Khuder
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Abstract

Background: Ohio remains one of the most afflicted states nationally with 46.3 per 100 000 deaths due to drug overdose. Opioids are commonly administered in emergency departments for the management of pain. Given the high volume of patients presenting with pain, emergency clinicians must be cognizant of responsible opioid dispensing practices. Ohio established guidelines in April 2012 to provide a general approach for responsible opioid prescribing practices in the emergency setting. The purpose of this study assesses clinician opioid dispensing before and after the implementation of the Ohio Opioid Prescribing Guidelines. Methods: The study design used retrospective data analysis of opioid medications ordered by emergency clinicians to be administered in the emergency room between January 1, 2007, to December 31, 2017, at the University of Toledo Medical Center. A segmented regression analysis with an interrupted time series was used to determine impact. Results: All opioid medication usage showed a significant decrease after guideline implementation except for morphine and fentanyl which showed statistically significant increases in administration over time (P < 0.05). Conclusion: There was a significant decrease in the use of opioids since the implementation of the Ohio Opioid Prescribing Guidelines, yet morphine and fentanyl use has generally increased across all age groups. Age demographics frequently receiving opioids in the emergency room have seemed to shift over time as well as specific opioid drugs dispensed for the management of pain in certain age groups. Further study is needed to evaluate the use of opioids prescribed by emergency physicians after discharge from the emergency department.
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阿片类药物在急性护理环境中的配药实践:一项回顾性研究
背景:俄亥俄州仍然是全国疫情最严重的州之一,每10万人中有46.3人死于药物过量。阿片类药物通常在急诊科用于治疗疼痛。鉴于大量患者出现疼痛,急诊临床医生必须认识到负责任的阿片类药物配药实践。俄亥俄州于2012年4月制定了指导方针,为在紧急情况下负责任的阿片类药物处方做法提供了一种通用方法。本研究的目的是评估临床医生在实施俄亥俄州阿片类药物处方指南前后的阿片类处方。方法:研究设计使用了2007年1月1日至2017年12月31日在托莱多大学医学中心急诊室由急诊临床医生订购的阿片类药物的回顾性数据分析。使用具有中断时间序列的分段回归分析来确定影响。结果:除吗啡和芬太尼外,所有阿片类药物的使用量在指南实施后均显著下降,吗啡和芬太尼的使用量随着时间的推移呈统计学显著增加(P<0.05),然而,吗啡和芬太尼的使用在所有年龄组中普遍增加。随着时间的推移,经常在急诊室接受阿片类药物治疗的年龄人口结构似乎发生了变化,在某些年龄组,为治疗疼痛而分配的特定阿片类药品也发生了变化。需要进一步的研究来评估急诊科医生出院后开具的阿片类药物的使用情况。
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