{"title":"The role of energy source or substrate in microbial hormesis","authors":"Liang Tang , Yang Zhou , Yulian Zhang , Haoyu Sun","doi":"10.1016/j.cotox.2021.12.001","DOIUrl":null,"url":null,"abstract":"<div><p>The hormetic dose–response has been frequently reported in a diverse set of microbial species. However, the role of energy source or substrate in microbial hormesis<span><span> has not attracted enough attention. Here, we review recently published studies regarding the hormetic phenomena of exogenous chemicals’ effects on microbes under different energy/substrate conditions. Energy/substrate could regulate metabolic activity, population density, carbon catabolite repression pathway, or </span>quorum sensing system to decide the survival strategies of microbes under exogenous stress, ultimately influencing the dose–response feature and even the occurrence of the hormetic phenomenon. This review highlights the key role of energy/substrate in microbial hormesis, which could not only provide a new insight into the investigation of hormetic effects in microbes but also promote the development of microbe-related fields.</span></p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"29 ","pages":"Pages 10-18"},"PeriodicalIF":6.1000,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"18","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468202021000735","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"TOXICOLOGY","Score":null,"Total":0}
引用次数: 18
Abstract
The hormetic dose–response has been frequently reported in a diverse set of microbial species. However, the role of energy source or substrate in microbial hormesis has not attracted enough attention. Here, we review recently published studies regarding the hormetic phenomena of exogenous chemicals’ effects on microbes under different energy/substrate conditions. Energy/substrate could regulate metabolic activity, population density, carbon catabolite repression pathway, or quorum sensing system to decide the survival strategies of microbes under exogenous stress, ultimately influencing the dose–response feature and even the occurrence of the hormetic phenomenon. This review highlights the key role of energy/substrate in microbial hormesis, which could not only provide a new insight into the investigation of hormetic effects in microbes but also promote the development of microbe-related fields.
期刊介绍：
The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
