Monitoring of cerebrospinal fluid dynamics in a model of brain herniation induced by acute intracranial hypertension by PC cine MRI

Q4 Nursing 中华急诊医学杂志 Pub Date : 2019-05-10 DOI:10.3760/CMA.J.ISSN.1671-0282.2019.05.011

周建国, Zhou Jianguo, 朱晓玲, Z. Xiaoling, 韦武鹏, Wei Wupeng, 黄丽轩, Huang Lixuan, 冯永彪, Feng Yongbiao, 张灵, Z. Ling, 马相飞, Mao Xiangfei, 李伟雄, Li Weixiong, 张剑锋, Z. Jianfeng, 欧和生, O. He-sheng, 唐华民, Tang Hua-min

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Abstract

Objective To explore the monitoring of cerebrospinal fluid (CSF) dynamics in a model of brain herniation induced by acute intracranial hypertension in Guangxi Bama-Mini pigs by phase-contrast cine magnetic resonance imaging (PC cine MRI). Methods Femoral artery blood were extracted from 10 pigs, and injected into the frontal and temporal parietal lobe to make a model of brain herniation induced by acute intracranial hypertension. The mean arterial blood pressure (MAP), intracranial pressure (ICP), and cerebral perfusion pressure (CPP) were monitored. Routine T1WI, T2WI, coronal, sagittal and cerebrospinal fluid flow sequence (fast PC cine slice) which positioned on the cervical 3 (C3) vertebral body as the center and perpendicular to the spinal scans were performed on all experimental animals before and after blood injection with 3.0T Magnetic Resonance Imaging. The ICP, MAP, CPP, the absolute values of CSF peak flow velocity and the absolute value of carotid peak flow velocity before and after blood injection were compared. Results The ICP, MAP , CPP, and the absolute value of CSF peak flow velocity before injection of autologous arterial blood were statistically significant as compared with those after blood injection [(6.80±2.044) mmHg vs (52.20±1.619) mmHg, (76.80±7.068) mmHg vs (142.80±12.399) mmHg, (70.00±6.074) mmHg vs (90.50±12.250) mmHg, and the absolute value of CSF peak flow velocity was (243.20±77.671) mm/s vs (201.40±55.482) mm/s, respectively, P 0.05]. Conclusion After the formation of brain herniation induced by acute intracranial hypertension, the CSF flow in the C3 level spinal canal showed a low dynamic change, and the CSF flow velocity waveform was disordered and malformed. The non-invasive measurement of CSF dynamics by PC cine MRI can provide an important basis for the change of CSF dynamics in the model of brain herniation induced by acute intracranial hypertension, and provide a theoretical basis for further research on damage control neurosurgery in the future. Key words: Phase-contrast cine magnetic resonance imaging; Cerebrospinal fluid dynamics; Intracranial hypertension; Brain herniation; Pig

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急性颅内压增高所致脑疝模型脑脊液动力学监测

目的探讨用相位对比电影磁共振成像（PC cine MRI）监测广西巴马小型猪急性颅内高压致脑疝模型的脑脊液动力学。方法从10头猪身上提取股动脉血，注入额颞顶叶，建立急性颅内高压致脑疝模型。监测平均动脉血压（MAP）、颅内压（ICP）和脑灌注压（CPP）。采用3.0T磁共振成像，对所有实验动物在注射血液前后进行T1WI、T2WI、冠状位、矢状位和脑脊液流动序列（快速PC电影片）常规扫描，定位于颈3（C3）椎体为中心，垂直于脊柱扫描。ICP、MAP、CPP、绝对值比较注射前后CSF峰值流速和颈动脉峰值流速的绝对值。结果ICP、MAP、CPP，注射自体动脉血前CSF峰值流速的绝对值与注射后相比有统计学意义[（6.80±2.044）mmHg vs（52.20±1.619）mmHg，（76.80±7.068）mmHg vs（142.80±12.399）mmHg、（70.00±6.074）mmHg vs90.50±12.250）mmHg；CSF峰值流速绝对值为（243.20±77.671）mm/s vs结论急性颅内高压致脑疝形成后，C3级椎管内CSF流量呈低动态变化，CSF流速波形紊乱、畸形。PC cine MRI对CSF动力学的无创测量，可以为急性颅内高压致脑疝模型中CSF动力学的变化提供重要依据，为未来损伤控制神经外科的进一步研究提供理论依据。关键词：相位对比电影磁共振成像；脑脊液动力学；颅内高压；脑疝；清管器

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来源期刊

中华急诊医学杂志 Nursing-Emergency Nursing

CiteScore

0.10

自引率

0.00%

发文量

8629

期刊介绍： Chinese Journal of Emergency Medicine is the only national journal which represents the development of emergency medicine in China. The journal is supervised by China Association of Science and Technology, sponsored by Chinese Medical Association, and co-sponsored by Zhejiang University. The journal publishes original research articles dealing with all aspects of clinical practice and research in emergency medicine. The columns include Pre-Hospital Rescue, Emergency Care, Trauma, Resuscitation, Poisoning, Disaster Medicine, Continuing Education, etc. It has a wide coverage in China, and builds up communication with Hong Kong, Macao, Taiwan and international emergency medicine circles.