Association of CAT C262T (rs1001179) polymorphism with male infertility: Meta-analysis

IF 0.8 Q4 GENETICS & HEREDITY Meta Gene Pub Date : 2021-12-01 DOI:10.1016/j.mgene.2021.100974
K.G. Savikina , A.H. Abd Ali , T.P. Shkurat , S.V. Lomteva , G.V. Karantysh
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引用次数: 1

Abstract

Background

In connection with the problems of infertility, one in four married couples in the world seek medical help because of the problems of the natural conception of a child. However, the biochemical and genetic mechanisms underlying male infertility are still poorly understood. This study aimed to identify a potential link between the –262C > T (rs1001179) polymorphism of the catalase (CAT) gene and pathospermia.

Methods

A total of 23 publications were analyzed up to July 2021, of which 5 case-control studies met all inclusion criteria. The analysis comprised a total of 1611 men: with pathospermia (n = 1082) and healthy donors (n = 529). Meta-analysis was performed using a “ fixed effects model” with a given OR and 95% confidence intervals for all models. The analysis of the “publication error” was carried out using the Begg and Egger tests. Then, the trial sequential analysis (TSA) was performed to assess association number of studies.

Results

Three studies have refer a correlation between the CAT-262C/C genotype and the risk of pathospermia. One study did not reveal a direct relationship between the rs1001179 polymorphism and pathospermia, and another study indicated an increased risk of pathospermia in carriers of the TT genotype. Based on the data of all analyzed studies, the odds ratio was calculated for the association of the rs1001179 polymorphism of the CAT gene with pathospermia; it was found that this value is 2.7 (OR = 0,73; 95% Cl = 0,57-0,92; p = 0.007).

Conclusion

Based on the results obtained, observed that the C-262 T locus of the CAT it is related with male infertility in various populations, but it requires more studies to confirm. As it can be assumed that the association of the CAT C262T (rs1001179) polymorphism with the development of pathospermia may vary depending on the ethnic group.

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CAT C262T (rs1001179)多态性与男性不育症的关联:meta分析
关于不孕不育问题,世界上四分之一的已婚夫妇因自然受孕问题而寻求医疗帮助。然而,男性不育的生物化学和遗传机制仍然知之甚少。本研究旨在确定-262C和-262C之间的潜在联系;过氧化氢酶(CAT)基因T (rs1001179)多态性与致病精子症。方法分析截至2021年7月共23篇文献,其中5篇病例对照研究符合所有纳入标准。该分析共包括1611名男性:病理精子症(n = 1082)和健康供体(n = 529)。使用“固定效应模型”进行meta分析,所有模型具有给定的OR和95%置信区间。对“发表误差”的分析使用贝格和埃格检验进行。然后,进行试验序列分析(TSA)来评估研究的关联数。结果有3项研究证实了CAT-262C/C基因型与致病精子症风险的相关性。一项研究没有揭示rs1001179多态性与致病精子症之间的直接关系,另一项研究表明TT基因型携带者患致病精子症的风险增加。根据所有分析研究的数据,计算CAT基因rs1001179多态性与致病精子症的比值比;结果发现该值为2.7 (OR = 0,73;95% Cl = 0,57 ~ 0,92;p = 0.007)。结论根据所获得的结果,观察到CAT的C-262 T位点在不同人群中与男性不育有关,但还需要更多的研究来证实。因为可以假设CAT C262T (rs1001179)多态性与致病精子症的发生的关联可能因民族而异。
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来源期刊
Meta Gene
Meta Gene Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
1.10
自引率
0.00%
发文量
20
期刊介绍: Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.
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