Gabriel Tao, Fatima Dagher, Ali Moballegh, Romi Ghose
{"title":"Role of oxidative stress in the efficacy and toxicity of herbal supplements","authors":"Gabriel Tao, Fatima Dagher, Ali Moballegh, Romi Ghose","doi":"10.1016/j.cotox.2020.04.004","DOIUrl":null,"url":null,"abstract":"<div><p>The importance of oxidative stress<span> has been increasingly recognized in diabetes and related cardiovascular complications as well as in chemical-induced toxicity, which makes it a potential therapeutic target for tackling such health issues. On the other hand, numerous herbal supplements have been reported effective to prevent diabetes and chemical-induced organ injury. Recently, emerging studies indicate that antioxidation is a possible mechanism responsible for the therapeutic effect of herbal extracts. Hereby, we reviewed the most recent studies regarding the antioxidant effect of herbal supplements. Also, we summarized the herbal extracts causing hepatotoxicity and nephrotoxicity via oxidative stress. We aim to highlight the importance of oxidative stress in the therapeutic effectiveness of herbal supplements, as well as in mediating their adverse effects.</span></p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"20 ","pages":"Pages 36-40"},"PeriodicalIF":3.6000,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2020.04.004","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468202020300346","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/5/6 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"TOXICOLOGY","Score":null,"Total":0}
引用次数: 7
Abstract
The importance of oxidative stress has been increasingly recognized in diabetes and related cardiovascular complications as well as in chemical-induced toxicity, which makes it a potential therapeutic target for tackling such health issues. On the other hand, numerous herbal supplements have been reported effective to prevent diabetes and chemical-induced organ injury. Recently, emerging studies indicate that antioxidation is a possible mechanism responsible for the therapeutic effect of herbal extracts. Hereby, we reviewed the most recent studies regarding the antioxidant effect of herbal supplements. Also, we summarized the herbal extracts causing hepatotoxicity and nephrotoxicity via oxidative stress. We aim to highlight the importance of oxidative stress in the therapeutic effectiveness of herbal supplements, as well as in mediating their adverse effects.
期刊介绍：
The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.
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