Success Rate of Sarem Protocol for Assisted Reproductive Techniques in Patients with Poor Ovarian Response

Abstract

Copyright© 2019, ASP Ins. This open-access article is published under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License which permits Share (copy and redistribute the material in any medium or format) and Adapt (remix, transform, and build upon the material) under the Attribution-NonCommercial terms. [1] Textbook of assisted reproductive technologies: Laboratory and clinical perspectives [2] Poor ovarian reserve [3] Decreased fertility in poor responder women is not related to oocyte morphological status [4] Obesity alters retrieved oocyte count and clinical pregnancy rates in high and poor responder women after in vitro fertilization [5] Human menopausal gonadotropin/human chorionic gonadotropin follicular maturation for oocyte aspiration: Phase II, 1981 [6] Evaluation of the results of ovulation induction with GnRH antagonist (Cetrotide) in patients with poor ovarian response in the previous ART cycle [7] Diminished ovarian reserve, causes, assessment and management [8] ESHRE consensus on the definition of ‘poor response'to ovarian stimulation for in vitro fertilization: The bologna criteria [9] Short gonadotropin-releasing hormone agonist versus flexible antagonist versus clomiphene citrate regimens in poor responders undergoing in vitro fertilization: A randomized controlled trial [10] Management of poor responders in IVF: Is there anything new [11] Comparison of different stimulation protocols used in in vitro fertilization: A review [12] Strategies for poor responders in IVF cycles [13] How to define, diagnose and treat poor responders? Responses from a worldwide survey of IVF clinics. Reproductive Biomed Online [14] A new more detailed stratification of low responders to ovarian stimulation: from a poor ovarian response to a low prognosis concept [15] The novel poseidon stratification of ‘low prognosis patients in assisted reproductive technology’ and its proposed marker of successful outcome [16] Effect of maternal age on the ovarian reserve markers, and pregnancy outcome in a sample of Kurdish women in Erbil city [17] Is the ovarian reserve influenced by vitamin D deficiency and the dress code in an infertile Iranian population? [18] Complete oocyte maturation arrest in art cycles [19] Relation between AMH level and ovarian reserve in infertile women candidate for assisted reproductive treatment [20] Treatment modalities in poor responder patients undergoing assisted reproductive techniques Aims One of the new challenges in the field of infertility in women is delaying pregnancy due to inadequate response of ovaries to ovulation induction drugs. Many studies have been conducted to provide therapeutic protocols in this regard, but there is not still sufficient and conclusive evidence to introduce a single treatment protocol. The aim of this study was to evaluate the success rate of Sarem Hospital protocol in patients with poor ovarian response to ART. Instrument & Methods This study is a descriptive cross-sectional study that was performed on 104 records in Sarem Hospital from 2015 to 2017 that was proved their poor ovarian response according to world criteria and were treated by Sarem Hospital protocol. Data were analyzed by SPSS software and Pearson correlation test. Findings Of 104 patients, 58 (55.8%) had infertility treatment and had a history of previous IVF and 46 patients (44.2%) did not receive any specific treatment. The mean duration of infertility was 5.11±4.67 years. The mean number of oocytes obtained from the current cycle was 4.79±2.98, which was 3.87 more than the number of oocytes of the previous cycle. The mean number of embryos formed was 2.69±1.75 and the number of transferred embryos was 2.10±0.96. Finally, 21 patients had positive βHCG test results and sonography showed FHR+ after three weeks. Conclusion The protocol approved in Sarem Hospital for patients with poor ovarian response to ART has the potential of 20.2% successful pregnancy. A B S T R A C T A R T I C L E I N F O