Structure and Biological Properties of 2-Phenylhydrazone Derivatives of Thiazolopyrimidines

IF 0.8 4区 化学 Q4 CHEMISTRY, MULTIDISCIPLINARY Doklady Chemistry Pub Date : 2022-06-20 DOI:10.1134/S0012500822030016
A. S. Agarkov, E. R. Gabitova, F. B. Galieva, A. S. Ovsyannikov, A. D. Voloshina, A. K. Shiryaev, I. A. Litvinov, S. E. Solovieva,  I. S. Antipin
{"title":"Structure and Biological Properties of 2-Phenylhydrazone Derivatives of Thiazolopyrimidines","authors":"A. S. Agarkov,&nbsp;E. R. Gabitova,&nbsp;F. B. Galieva,&nbsp;A. S. Ovsyannikov,&nbsp;A. D. Voloshina,&nbsp;A. K. Shiryaev,&nbsp;I. A. Litvinov,&nbsp;S. E. Solovieva,&nbsp; I. S. Antipin","doi":"10.1134/S0012500822030016","DOIUrl":null,"url":null,"abstract":"<p>A number of 2-phenylhydrazone derivatives of thiazolo[3,2-<i>a</i>]pyrimidines has been synthesized, and their structure and biological activity have been studied. The structure of the obtained compounds has been confirmed by <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy and X-ray diffraction analysis. It has been found that hydrazone form with <i>Z</i> configuration of the C=N bond is typical for the obtained derivatives. Low cytotoxicity of the synthesized compounds toward normal and tumor cell lines has been shown.</p>","PeriodicalId":530,"journal":{"name":"Doklady Chemistry","volume":"503 1","pages":"45 - 50"},"PeriodicalIF":0.8000,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Doklady Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S0012500822030016","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 4

Abstract

A number of 2-phenylhydrazone derivatives of thiazolo[3,2-a]pyrimidines has been synthesized, and their structure and biological activity have been studied. The structure of the obtained compounds has been confirmed by 1H and 13C NMR spectroscopy and X-ray diffraction analysis. It has been found that hydrazone form with Z configuration of the C=N bond is typical for the obtained derivatives. Low cytotoxicity of the synthesized compounds toward normal and tumor cell lines has been shown.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
噻唑嘧啶2-苯基腙衍生物的结构和生物学性质
合成了一些噻唑[3,2- A]嘧啶的2-苯基腙衍生物,并对其结构和生物活性进行了研究。所得化合物的结构经1H、13C核磁共振谱和x射线衍射分析证实。得到的衍生物以C=N键的Z构型为典型的腙构型。合成的化合物对正常和肿瘤细胞系具有较低的细胞毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Doklady Chemistry
Doklady Chemistry 化学-化学综合
CiteScore
1.20
自引率
12.50%
发文量
7
审稿时长
6-12 weeks
期刊介绍: Doklady Chemistry is a journal that publishes new research in chemistry and chemical engineering of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.
期刊最新文献
Synthesis of Polyfunctional O-Containing Compounds with Acetal Fragment by Low-Temperature Ozonolysis of 1,3-Dioxepins Doped Silicon Nanoparticles. A Review Evaluation of Toxicity of Ionic Liquids as Solvents in C–C Cross-coupling Reaction Antifriction Composites Based on a Two-Component Modified Phenol–Formaldehyde Binder Synthesis of Novel Composite Sorbents Based on Titanium, Calcium, and Magnesium Phosphates
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1