Patterns of prescription and adverse drug reaction profile of Non- Steroidal Anti-Inflammatory Drugs at orthopedic out-patients department

G. Neupane, Maya Rai, P. Rokaya
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Abstract

Non-steroidal Anti-inflammatory Drugs (NSAIDs) are the most prescribed drugs all over the world. These are used in the treatment of pain and inflammation. Systematic evaluation of prescription patterns and monitoring of adverse drug reactions is required to increase the therapeutic benefit and decrease the adverse effects of these drugs. An observational, cross-sectional study was conducted for 6 months from September 2021 to February 2022 in 300 patients prescribed least one NSAID to assess the prescription patterns and adverse drug reaction profile (ADR) of NSAIDs prescribed in the orthopedic outpatient department. Among enrolled patients 52% were female and 48% were male. The most common age group was 20-39. The average number of drugs per prescription was 2.89. A total of 868 drugs were prescribed, out of which 402 were NSAIDs (46.31%). Naproxen was the most prescribed agent (45.02%), followed by Diclofenac (17.17%). ADR was reported in 12% of patients. Most of the ADRs were due to Naproxen (72.18%) followed by Ibuprofen (16.66%). The gastrointestinal system was involved in maximum patients and the most common ADR was abdominal pain. Most of the drugs were prescribed by brand name 95.18%. Naproxen was the most prescribed NSAID and responsible for most ADRs. There was a higher prevalence of irrational prescribing, polypharmacy, and underreporting of ADR. A strategy must be developed and implemented for prescribing and rational use of NSAIDs and monitoring their harmful effects.
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骨科门诊非甾体抗炎药处方模式及不良反应分析
非甾体抗炎药(NSAIDs)是世界上处方最多的药物。这些药物用于治疗疼痛和炎症。需要对处方模式进行系统评估并监测药物不良反应,以提高这些药物的治疗效益并减少不良反应。从2021年9月到2022年2月,对300名至少服用一种非甾体抗炎药的患者进行了为期6个月的观察性横断面研究,以评估骨科门诊处方非甾体类抗炎药的处方模式和不良反应(ADR)。入选患者中52%为女性,48%为男性。最常见的年龄组是20-39岁。每个处方的平均药物数量为2.89。共开出868种药物,其中402种是非甾体抗炎药(46.31%)。萘普生是处方最多的药物(45.02%),其次是双氯芬酸(17.17%)。12%的患者报告了ADR。大多数不良反应是由萘普生引起的(72.18%),其次是布洛芬(16.66%)。大多数患者涉及胃肠系统,最常见的不良反应是腹痛。大多数药物的处方为品牌名称95.18%。萘普生是处方最多的非甾体抗炎药,也是造成大多数不良反应的原因。不良反应的不合理处方、多药治疗和漏报率较高。必须制定和实施非甾体抗炎药的处方和合理使用以及监测其有害影响的策略。
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