Effects of Xylopia Aethiopica Leaf Extract on The Renal Function, Liver Enzymes and Antioxidants Status of Albino Rats

Abstract

Aim: To determine effects of Xylopia aethiopica leaf extract on urea, creatinine, Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Vitamin C and Vitamin E levels of albino rats. Material and Methods: Thirty-five albino rats were randomly divided into five groups with seven rats in each group (n=7); Control (C) received normal feed only. Group 1: was administered with Xylopia aethiopica leaf extract 100 mg/kg, Group 2: Xylopia aethiopica extract 150 mg/kg, Group3: Xylopia aethiopica leaf extract 200 mg/kg. Group 4: received Xylopia aethiopica leaf extract 250 mg/kg. This lasted for 28 days. Results: Group 3 and 4 showed significantly decreased urea (18.88±0.23mg/dl, 18.04± 0.56mg/dl,) creatinine (0.55±0.03mg/dl, 0.49±0.03mg/dl) AST (18.19±0.33iu/l, 18.05±0.32iu/l) and ALT (13.72±0.23iu/l, 13.58± 0.66iu/l) when compared with the control (urea 21.4±1.36mg/dl, Creatinine 0.73±0.06iu/l, AST 18.61±0.33, ALT 14.14±0.28) respectively at p < 0.05. While Group 3 and 4 showed significantly increased vit C and E levels when compared with the control at p < 0.05. Conclusion: Xylopia aethiopica leaf extract has an antioxidant effect as well heptoprotective and renal protective effect.