Two new supramolecular Ag(I) coordination polymers: luminescent properties and treatment activity on glioblastoma

IF 1.8 4区化学 Q3 POLYMER SCIENCE Designed Monomers and Polymers Pub Date : 2022-02-25 DOI:10.1080/15685551.2022.2041785

Xiao-Feng Yan, Yu-Qiang Sun, Qing-Wei Li

引用次数: 0

Abstract

ABSTRACT Two new Ag(I) coordination polymers, namely [Ag(bpp)]·0.5 n(1,5-NDSA)·n(H2O) (1) and [Ag2(bpp)2]n·n(2,7-NDSA)·2 n(H2O)·n(CH3CN) (2) (Na2(1,5-NDSA) = sodium 1,5-naphthalenedisulfonate dibasic, Na2(2,7-NDSA) = sodium 1,5-naphthalenedisulfonate dibasic, bpp is 1,3-bis(4-pyridyl)propane), were generated via the solution evaporation method under room temperature. Moreover, the solids of these two compounds display strong luminescence emission at RT. And the application values of the compounds against the glioblastoma treatment were determined, and the corresponding mechanism was simultaneously tested. The analysis of CCK-8 was first implemented and the glioblastoma viability was measured. The real-time RT-PCR was next performed, and the signaling pathway activation of VEGF in glioblastoma cells was tested after treating by the above compound.

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两种新型超分子Ag（I）配位聚合物的发光性能及其对胶质母细胞瘤的治疗作用

摘要:采用室温溶液蒸发法制备了[Ag(bpp)]·0.5 n(1,5- ndsa)·n(H2O)(1)和[Ag2(bpp)2]n·n(2,7- ndsa)·2n (H2O)·n(CH3CN) (2) (Na2(1,5- ndsa) = 1,5-萘二磺酸钠二碱性，Na2(2,7- ndsa) = 1,5-萘二磺酸钠二碱性，bpp为1,3-双(4-吡啶基)丙烷))两种新型Ag(I)配位聚合物。此外，这两种化合物的固体在rt下表现出较强的发光发射，并确定了化合物对胶质母细胞瘤治疗的应用价值，同时测试了相应的机制。首先进行CCK-8的分析，并测量胶质母细胞瘤的生存能力。然后进行实时RT-PCR，检测上述化合物作用于胶质母细胞瘤细胞后VEGF的信号通路激活情况。

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来源期刊

Designed Monomers and Polymers 化学-高分子科学

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

2.1 months

期刊介绍： Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work. The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications. DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to: -macromolecular science, initiators, macroinitiators for macromolecular design -kinetics, mechanism and modelling aspects of polymerization -new methods of synthesis of known monomers -new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization) -functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers -new polymeric materials with biomedical applications