Vitamin D Physiology, Deficiency, Genetic Influence, and the Effects of Daily vs. Bolus Doses of Vitamin D on Overall Health: A Clinical Approach

Vincenzo Sorrenti, A. Buriani, S. Davinelli, G. Scapagnini, Stefano Fortinguerra
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引用次数: 1

Abstract

Vitamin D is a pleiotropic hormone that plays a vital role in regulating bone growth, maintaining calcium and phosphate homeostasis, modulating immune function, and a wide range of other pleiotrophic actions in humans, which have increased the attention for its clinical applications. Despite its importance, vitamin D deficiency is prevalent worldwide and is related to a range of pathophysiological conditions, including an increased risk of osteoporosis and chronic and autoimmune diseases. The recommended daily doses of vitamin D vary depending on genetics, age, sex, and health status, with specific doses recommended for infants, children, adults, and those at increased risk of deficiency or specific health conditions. Maintaining adequate vitamin D levels is essential for optimal health, and together with sun exposure, appropriate supplementation strategies can help achieve this goal. Vitamin D supplementation is commonly used to maintain adequate levels, and the optimal administration strategy, such as a daily dose vs. a bolus, is still being investigated. This review aims to understand vitamin D physiology and the impact of relevant vitamin D polymorphisms and to evaluate the role of a daily dose versus a bolus in maintaining optimal vitamin D levels and clinical health outcomes. It also provides suggested clinical guidelines for clinicians based on the most recent scientific evidence.
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维生素D生理,缺乏,遗传影响,以及每日与大剂量维生素D对整体健康的影响:临床方法
维生素D是一种多效性激素,在调节骨骼生长、维持钙和磷酸盐平衡、调节免疫功能等多种人体多效性活动中起着重要作用,其临床应用日益受到关注。尽管维生素D缺乏症很重要,但它在世界范围内普遍存在,并与一系列病理生理状况有关,包括骨质疏松症、慢性和自身免疫性疾病的风险增加。维生素D的每日推荐剂量因基因、年龄、性别和健康状况而异,并为婴儿、儿童、成人以及那些缺乏维生素D风险增加或有特定健康状况的人推荐特定剂量。维持足够的维生素D水平对最佳健康至关重要,适当的补充策略与阳光照射一起可以帮助实现这一目标。维生素D补充剂通常用于维持足够的水平,而最佳的给药策略,如每日剂量与丸剂,仍在研究中。本综述旨在了解维生素D生理学和相关维生素D多态性的影响,并评估每日剂量与大剂量在维持最佳维生素D水平和临床健康结果方面的作用。它还根据最新的科学证据为临床医生提供了建议的临床指南。
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