Aorta pathology and pregnancy-related risks in adult congenital cardiac disease: does the aorta dilate during pregnancy?

IF 0.8 Q4 OBSTETRICS & GYNECOLOGY Obstetric Medicine Pub Date : 2024-03-01 Epub Date: 2023-02-28 DOI:10.1177/1753495X231156851

Anne-Sophie Ceuppens, Pieter De Meester, Alexander Van De Bruaene, Jens-Uwe Voigt, Kristel Van Calsteren, Werner Budts, Els Troost

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Abstract

Background: Aortic dilatation and pregnancy are major concerns in women with aortopathy (AOP). This single-centre retrospective analysis focuses on the evolution of aortic diameters during and after pregnancy in women with Marfan syndrome (MS), Turner syndrome (TS) and bicuspid aortic valve (BAV) aortopathy.

Methods and results: Thirty-eight women who had one or more single pregnancies were included. The ascending aorta was measured during pregnancy and postpartum. During pregnancy, a significant increase of diameters of the sinus aortae (median 1.4 mm; [-1.3; 3.8]) and ascending aorta (median 2.1 mm; [0.0; 4.0]) was noted. Systemic hypertension gives dilation of the aorta, but it did not influence the overall trajectory during pregnancy.

Conclusion: Significant aortic dilatation is noted during pregnancy in women with underlying AOP, even persisting in the long term. Pre-existing systemic hypertension is associated with larger aortic diameters prior to pregnancy. More research on a larger study population however is needed.

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成人先天性心脏病的主动脉病理和妊娠相关风险:妊娠期间主动脉扩张吗?

主动脉扩张和妊娠是患有主动脉病（AOP）的女性主要关注的问题。这项单中心回顾性分析的重点是患有Marfan综合征（MS）、Turner综合征（TS）和双叶主动脉瓣（BAV）主动脉病变的女性在怀孕期间和怀孕后主动脉直径的演变。其中包括38名有一次或多次单胎妊娠的妇女。在妊娠期和产后测量升主动脉。妊娠期间，主动脉窦直径显著增加（中位数1.4 mm；[-1.3；3.8]）和升主动脉（中位数2.1 mm；[0.0；4.0]）。系统性高血压会使主动脉扩张，但不会影响妊娠期间的总体轨迹。有潜在AOP的女性在怀孕期间出现明显的主动脉扩张，甚至长期持续。妊娠前存在的系统性高血压与较大的主动脉直径有关。然而，还需要对更大的研究人群进行更多的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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