Formulation and Optimisation of Microspheres of Leaves extract of Lantana camara 32 Design Approach

Abstract

The leaf extracts of plant Lantana camara shows significant antithrombin and thrombolytic activity. Modified release form of extract will show better therapeutics efficiency. In this work the extracts of plant L. camara-loaded polycaprolactone microspheres were prepared using the double emulsion method. 32 design approaches were used for the optimization of polycaprolactone and PVP concentration for response entrapment efficiency (Y1) and drug release (Y2). The microspheres of L. camara were analyzed for EE, FTIR, DSC, XRD and drug release. The entrapment efficiency of L. camara microspheres was in ranges of 62.25 to 84.04%. The particle size of optimized batch of microspheres was 789.6 (d. nm) with PDI 0.838. It shows pH dependant swelling with no interaction between drug and polymer was observed in DSC studies. The % drug release of all thirteen batches was in ranges of 87.91 to 99.04% for 12 hours duration. From the study we conclude the prepared L. camara loaded polycaprolactone microspheres show sustained release action for 12 hours.