Comparison Between Dexamethasone and Fentanyl as an Adjuvant to Bupivacaine and Lignocaine in Supraclavicular Brachial Plexus Block for Upper Limb Surgery

IF 0.4 Q4 PHARMACOLOGY & PHARMACY Journal of Pharmacology & Pharmacotherapeutics Pub Date : 2022-03-01 DOI:10.1177/0976500X221085803
Shilpa Kore, Smita Bhau Ubhe, Fathima Fasil
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引用次数: 1

Abstract

Objective: To compare the effects of dexamethasone and fentanyl when added to a mixture of bupivacaine and lignocaine in supraclavicular blocks in patients undergoing forearm surgeries. Methods: Sixty-six patients aged between 20 to 60 years old belonging to ASA one or two were recruited prospectively, double-blinded, and randomized way. Supraclavicular block under sonographic guidance was performed in the three groups by using injection bupivacaine (0.5%) 20 cc + injection lignocaine (2%) 10 cc + injection 0.9% normal saline; 2ml (Group S), injection bupivacaine (0.5%) 20 cc + injection lignocaine (2%) 10 cc + injection dexamethasone 8 mg (Group D), and injection bupivacaine (0.5%) 20 cc + injection lignocaine (2%) 10 cc + injection fentanyl 50 µgm (Group F). The onset time of sensory and motor block, duration of sensory and motor block, and hemodynamic variables were recorded. Results: Group D showed a significantly greater sensory and motor block duration than other groups (P = 0.001). Comparison of hemodynamic variables failed to reveal any statistically significant differences between all the groups. Conclusion: Both dexamethasone and fentanyl are good adjuvants in the supraclavicular block, but dexamethasone is better, given faster onset and duration of analgesia.
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地塞米松和芬太尼辅助布比卡因和利多卡因在锁骨上臂丛阻滞上肢手术中的比较
目的:比较地塞米松和芬太尼与布比卡因和利多卡因混合治疗前臂手术患者锁骨上阻滞的效果。方法:前瞻性、双盲、随机法招募66例年龄在20 ~ 60岁,属于ASA 1级或2级的患者。三组在超声引导下行锁骨上阻滞:注射布比卡因(0.5%)20 cc +注射利多卡因(2%)10 cc +注射0.9%生理盐水;2ml (S组),注射布比卡因(0.5%)20 cc +注射利多卡因(2%)10 cc +注射地塞米松8 mg (D组),注射布比卡因(0.5%)20 cc +注射利多卡因(2%)10 cc +注射芬太尼50µgm (F组)。记录感觉和运动阻滞发生时间、感觉和运动阻滞持续时间及血流动力学指标。结果:D组感觉和运动阻滞持续时间明显长于其他组(P = 0.001)。血流动力学变量的比较没有显示各组之间有统计学上的显著差异。结论:地塞米松和芬太尼都是锁骨上阻滞的良好佐剂,但地塞米松效果更好,起效更快,镇痛时间更长。
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