Screening of bone cements loaded with antituberculosis drugs: preparation and determination of physical properties

中华实验外科杂志 Pub Date : 2019-12-08 DOI:10.3760/CMA.J.ISSN.1001-9030.2019.12.041

Hucheng Yuan, Mao Wenxin, Qian Wang, Zili Wang, Jiancun Lei, Q. Liang, Guangwei Sun, Xuehua Ma, Zhen Liu, Xiaoming Zhang, Jianghua Du

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Abstract

Objective To explore the physical properties of bone cements loaded with atituberculosis drugs. Methods We mixed ten drugs with four bone cements by 1.5 g∶40.0 g and 2.5 g∶40.0 g, 400 modules of 80 groups were maded according to the ISO. The control group mixed bone cements with their liquid monomer, 20 modules of 4 groups were maded. The physical properties were measured respectively. Results Group 1.5 g and 2.5 g of E, Z, S, C, A, M mixed with Palacos R, Palacos MV, Simplex P, the average dough time, solidification time, maximum temperature and mechanical strength were all meet ISO, and hardened in 20 minutes after mixing. Group 1.5 g and 2.5 g of R, H, Rt, and P mixed with the bone cements above, the average dough time, solidification time were all >ISO, the average maximum temperature was 0.05) between the four kinds of bone cements. The flexural strength and flexural modulus (P<0.01) were different. The physical properties of Palacos R and Simplex P bone cements meet ISO. The flexural strength and flexural modulus of CEMEX XL bone cement were

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抗结核药物负载骨水泥的筛选:制备和物理性质的测定

目的探讨抗结核药物负载骨水泥的物理性能。方法将10种药物与4种骨水泥按1.5 g∶40.0 g和2.5 g∶40.0 g的比例混合，按ISO标准制作80组共400个模块。对照组将骨水泥与其液体单体混合，制作4组共20个模块。分别测定了其物理性能。结果1.5 g和2.5 g E、Z、S、C、A、M与Palacos R、Palacos MV、Simplex P混合后，平均面团时间、凝固时间、最高温度和机械强度均满足ISO要求，并在混合后20 min内硬化。1.5 g和2.5 g R、H、Rt、P与以上4种骨水泥混合后，4种骨水泥的平均成型时间、凝固时间均为>ISO，平均最高温度为0.05)。抗弯强度和抗弯模量差异有统计学意义(P<0.01)。Palacos R和Simplex P骨水泥的物理性能符合ISO标准。CEMEX XL骨水泥抗弯强度和抗弯模量均

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