{"title":"Arypiprazol w dawce maksymalnej 30 mg i w połączeniu z olanzapiną","authors":"Paweł Mierzejewski","doi":"10.5603/psych.2020.0013","DOIUrl":null,"url":null,"abstract":"Aripiprazole is an antipsychotic drug with unique pharmacological properties showing ago-antagonistic effects against the D2 receptor and is classified as a III generation antipsychotic. Clinical and preclinical studies indicate efficacy and safety of high doses of aripiprazole in selected patients, supporting the decision to use the drug at a maximum dose of 30 mg/day. This paper presents the mechanism of action of high doses of aripiprazole and discusses clinical situations when it is appropriate to use the drug at the maximum dose. The second part of the study presents arguments for beneficial effects of the combination of aripiprazole with olanzapine and other antipsychotic drugs of II generation.","PeriodicalId":39960,"journal":{"name":"Psychiatria","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychiatria","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5603/psych.2020.0013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Aripiprazole is an antipsychotic drug with unique pharmacological properties showing ago-antagonistic effects against the D2 receptor and is classified as a III generation antipsychotic. Clinical and preclinical studies indicate efficacy and safety of high doses of aripiprazole in selected patients, supporting the decision to use the drug at a maximum dose of 30 mg/day. This paper presents the mechanism of action of high doses of aripiprazole and discusses clinical situations when it is appropriate to use the drug at the maximum dose. The second part of the study presents arguments for beneficial effects of the combination of aripiprazole with olanzapine and other antipsychotic drugs of II generation.
期刊介绍：
"Psychiatry" is a quaternary journal addressed to professionals coming from all branches of psychiatry practicing in both hospital and outpatients departments. "Psychiatry" issues original articles, reviews, case reports, commentaries, and translated articles from leading journals in the field of psychiatry. The papers are reviewed by the members of the editorial board. "Psychiatry" also publishes the practice guidelines in sexology. Psychopharmacotherapy is the main field of interests of the quatrernary.
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