Sonic Hedgehog Signaling Activation Promotes Cardioprotective Strategies

Q3 Medicine Current Signal Transduction Therapy Pub Date : 2020-06-30 DOI:10.2174/1574362413666181113124958

Himanshi Khera, Anupam Awasthi, S. Mehan

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Abstract

Hedgehog pathway plays a crucial role in the neovascularisation and angiogenesis during the embryonic stage in humans. Three genes of hedgehog protein isolated from humans are Sonic hedgehog, Desert hedgehog and Indian hedgehog gene. Two G-protein coupled receptors identified in the sonic hedgehog pathway served as patched receptor and smoothened receptor. Particularly, sonic hedgehog gene plays a versatile role in cellular homeostasis and can be a novel therapeutic target in the prevention of cardiovascular disorders. Further various sonic hedgehog modulators have been reported working as futuristic drug molecules in the modulation of cardiovascular dysfunctions. However, there was limited literature availability that has summarized the possible mechanism of targeting Sonic hedgehog signaling pathway. Thus, the present review is aimed at exploring the role of targeting sonic hedgehog protein signaling and modulators as well as to enlighten that how targeting sonic hedgehog protein involves in the amelioration of atherosclerosis, ischemic heart diseases, vascular endothelial dysfunction, heart failure and congenital heart diseases.

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Sonic Hedgehog信号激活促进心脏保护策略

Hedgehog通路在人类胚胎期的新生血管形成和血管生成中起着至关重要的作用。从人类身上分离到三个刺猬蛋白基因，分别是声波刺猬基因、沙漠刺猬基因和印度刺猬基因。在声波刺猬通路中发现的两个G蛋白偶联受体分别作为修补受体和平滑受体。特别是，声波刺猬基因在细胞稳态中发挥着广泛的作用，可以成为预防心血管疾病的新的治疗靶点。据报道，各种各样的声波刺猬调节剂可以作为未来的药物分子调节心血管功能障碍。然而，现有的文献综述了靶向Sonic hedgehog信号通路的可能机制。因此，本综述旨在探索靶向声波刺猬蛋白信号传导和调节剂的作用，并阐明靶向声波hedgehog蛋白如何改善动脉粥样硬化、缺血性心脏病、血管内皮功能障碍、心力衰竭和先天性心脏病。

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来源期刊

Current Signal Transduction Therapy 医学-药学

CiteScore

1.70

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： In recent years a breakthrough has occurred in our understanding of the molecular pathomechanisms of human diseases whereby most of our diseases are related to intra and intercellular communication disorders. The concept of signal transduction therapy has got into the front line of modern drug research, and a multidisciplinary approach is being used to identify and treat signaling disorders. The journal publishes timely in-depth reviews, research article and drug clinical trial studies in the field of signal transduction therapy. Thematic issues are also published to cover selected areas of signal transduction therapy. Coverage of the field includes genomics, proteomics, medicinal chemistry and the relevant diseases involved in signaling e.g. cancer, neurodegenerative and inflammatory diseases. Current Signal Transduction Therapy is an essential journal for all involved in drug design and discovery.