Acute myocardial infarction – a historical review

N. Gotcheva
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Abstract

The last 120 years have witnessed famous physicians and pathologists connected their medical investigation to study pathophysiology, diagnostics and treatment of acute myocardial infarction (AMI). Modern treatment algorithms based on precise and refi ned new technologies have as a main target to achieve rapid reperfusion and salvage threatened myocardium in order to enhance patients’ recovery and also to decrease mortality rate. Although long-lasting and multiple studies appeared to have impressive results, there still exist unknown or disputable viewpoints/concepts concerning for example the appearance of the reperfusion injuries, left ventricular remodeling, AMI in patients with normal coronary arteries, identifi cation of vulnerable lesions or plaques which are threatened by rupture or fi ssuring. This short historical review is aimed to remind us the evolution of the AMI knowledge and also to pull out some of the forgotten but relevant milestone hypothesis, as well as to help shaping the modern management of AMI.
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急性心肌梗死的历史回顾
在过去的120年里,著名的医生和病理学家将他们的医学研究结合起来,研究急性心肌梗死(AMI)的病理生理学、诊断和治疗。现代治疗算法基于精确和完善的新技术,以实现快速再灌注和挽救危重心肌,以提高患者的恢复和降低死亡率为主要目标。尽管长期和多项研究似乎取得了令人印象深刻的结果,但仍然存在未知或有争议的观点/概念,例如再灌注损伤的外观,左心室重构,正常冠状动脉患者的AMI,易损病变或斑块的识别,这些病变或斑块可能破裂或破裂。这篇简短的历史回顾旨在提醒我们AMI知识的演变,并提出一些被遗忘但相关的里程碑假设,以及帮助塑造AMI的现代管理。
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CiteScore
0.10
自引率
0.00%
发文量
40
审稿时长
12 weeks
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