P. Pandey, N. Minocha, N. Vashist, Rashmi Shah, Sapna Saini, Manish Makhija, Deepika Purohit, D. Kaushik
{"title":"Emulgel: An Emerging Approach towards Effective Topical Drug Delivery","authors":"P. Pandey, N. Minocha, N. Vashist, Rashmi Shah, Sapna Saini, Manish Makhija, Deepika Purohit, D. Kaushik","doi":"10.2174/2210303112666220818115231","DOIUrl":null,"url":null,"abstract":"\n\nDuring the development of the new formulations, the hydrophobic drugs\nface many problems leading to poor water solubility and problems related to bioavailability. Topical\ndrug delivery is a popular and unique process that directs the action of various drugs on the skin for\nthe treatment and diagnosis of various diseases and disorders such as urticaria, inflammation, rheumatism, etc. This topical release system is usually used to escape the first-pass metabolism. An\nemulgel is a superior formulation with combined advantages of both an emulsion and agel. Gel\npreparations normally offer earlier drug release than other predictable ointments and creams.\n\n\n\nThe main aim of this review is to deal with the problems associated with the delivery of\nhydrophobic drugs and to tackle these problems using an emulgel formulation. Emulgel mainly\nprovides better stability, prolonged local contact, controlled release of drugs with short half-life, and\nbetter loading capacity.\n\n\n\nThe review was extracted from the searches performed in PubMed, Google Patents, Medline, and Google Scholars, etc. Data from these searches were collected and evaluated to get information about the available literature on the emulgel formulation. The literature obtained was studied\nthoroughly as per the requirement of the objective of this review.\n\n\n\nThe details of the emulgel formulation, the advantages and disadvantages associated with\nit, and the methods for characterization of the formulation are compiled here in this review. Along\nwith this, some reported patents have also been included in this review to conclude the future of\nemulgel formulation in topical drug delivery.\n\n\n\nEmulgel is becoming very popular as a drug delivery system to deliver many antifungal, analgesics, anti-acne, anti-inflammatory drugs, and a number of cosmetics with a wide scope to\nbe explored further. This review article is motivated by the formulation, characterization, patents,\nand biological activities of emulgel formulation.\n","PeriodicalId":11310,"journal":{"name":"Drug Delivery Letters","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Delivery Letters","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/2210303112666220818115231","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 2
Abstract
During the development of the new formulations, the hydrophobic drugs
face many problems leading to poor water solubility and problems related to bioavailability. Topical
drug delivery is a popular and unique process that directs the action of various drugs on the skin for
the treatment and diagnosis of various diseases and disorders such as urticaria, inflammation, rheumatism, etc. This topical release system is usually used to escape the first-pass metabolism. An
emulgel is a superior formulation with combined advantages of both an emulsion and agel. Gel
preparations normally offer earlier drug release than other predictable ointments and creams.
The main aim of this review is to deal with the problems associated with the delivery of
hydrophobic drugs and to tackle these problems using an emulgel formulation. Emulgel mainly
provides better stability, prolonged local contact, controlled release of drugs with short half-life, and
better loading capacity.
The review was extracted from the searches performed in PubMed, Google Patents, Medline, and Google Scholars, etc. Data from these searches were collected and evaluated to get information about the available literature on the emulgel formulation. The literature obtained was studied
thoroughly as per the requirement of the objective of this review.
The details of the emulgel formulation, the advantages and disadvantages associated with
it, and the methods for characterization of the formulation are compiled here in this review. Along
with this, some reported patents have also been included in this review to conclude the future of
emulgel formulation in topical drug delivery.
Emulgel is becoming very popular as a drug delivery system to deliver many antifungal, analgesics, anti-acne, anti-inflammatory drugs, and a number of cosmetics with a wide scope to
be explored further. This review article is motivated by the formulation, characterization, patents,
and biological activities of emulgel formulation.
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