Physiochemical Characterization and in vitro Evaluation of Formulated Herbal Bioactive Loaded Transdermal Patches

IF 0.7 Q4 PHARMACOLOGY & PHARMACY Pharmacognosy Research Pub Date : 2022-12-15 DOI:10.5530/097484900244

Pooja Raj Verma, Neelesh Maheshwari, Deepika Bairagee

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引用次数: 1

Abstract

Aim: The present research aimed to formulate a transdermal patch incorporating herbal bioactive Vitex negundo extract. The polymers that were used for selected sustained release of the drug are HPMC, PVP K30 and polyethylene glycol used as a plasticizer. Materials and Methods: Transdermal patches were prepared using the drug with two (HPMC and PVP K30) different polymers. The prepared transdermal films were evaluated for their physico-chemical characteristics such as physical appearance, weight uniformity, thickness, folding endurance, moisture content, drug content, percent moisture loss and permeation studies. The skin irritation study done on rat skin showed that the formulation does not produce irritation to the skin it showed the successful release of drug from the fabricated patch. Results: The in vitro release of formulation F1, F2, F3, F4, F5 and F6 has shown release of about 89.15%, 87.12%, 82.34%, 92.45%, 86.78% and 76.21% at 8hr. The order of drug release was found to be F4>F1>F2>F3>F6>F5. Conclusion: It could be concluded that it was concluded from the study, that the transdermal patch containing herbal bioactive Vitex negundo F4 batch showed the highest percent of drug release and other desirable properties can be developed.

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中药生物活性透皮贴剂的理化性质及体外评价

目的：本研究旨在制备一种含有生物活性中药黄荆提取物的透皮贴剂。用于选择药物缓释的聚合物是HPMC、PVP K30和用作增塑剂的聚乙二醇。材料和方法：使用该药物与两种不同的聚合物（HPMC和PVP K30）制备透皮贴剂。评价了所制备的透皮膜的物理化学特性，如物理外观、重量均匀性、厚度、耐折叠性、水分含量、药物含量、水分损失百分比和渗透研究。对大鼠皮肤进行的皮肤刺激性研究表明，该制剂不会对皮肤产生刺激——它表明药物从制作的贴片中成功释放。结果：制剂F1、F2、F3、F4、F5和F6的体外释放度分别为89.15%、87.12%、82.34%、92.45%、86.78%和76.21%。药物释放顺序为F4＞F1＞F2＞F3＞F6＞F5。结论：本研究得出结论，含有中药生物活性黄荆F4批次的透皮贴剂具有最高的释药率，可以开发出其他理想的性质。

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来源期刊

Pharmacognosy Research PHARMACOLOGY & PHARMACY-

自引率

14.30%

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期刊介绍： Pharmacognosy Research [ISSN: Print -0976-4836, Online - 0974-8490] [http://www.phcogres.com], Quarterly a publication of Phcog.Net is published by Wolters Kluwer - Medknow Publications. It provides peer-reviewed original research articles from the field of Natural Products. The journal serves an international audience of scientists and researchers in a variety of research and academia by quickly disseminating research findings related to Medicinal Plants and Natural Products. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submissions of original contributions in all areas of pharmacognosy are welcome.