Microfluidic-based technologies for diagnosis, prevention, and treatment of COVID-19: recent advances and future directions

IF 3 4区医学 Q3 ENGINEERING, BIOMEDICAL Biomedical Microdevices Pub Date : 2023-03-13 DOI:10.1007/s10544-023-00649-z

E. Alperay Tarim, Muge Anil Inevi, Ilayda Ozkan, Seren Kecili, Eyup Bilgi, M. Semih Baslar, Engin Ozcivici, Ceyda Oksel Karakus, H. Cumhur Tekin

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引用次数: 5

Abstract

The COVID-19 pandemic has posed significant challenges to existing healthcare systems around the world. The urgent need for the development of diagnostic and therapeutic strategies for COVID-19 has boomed the demand for new technologies that can improve current healthcare approaches, moving towards more advanced, digitalized, personalized, and patient-oriented systems. Microfluidic-based technologies involve the miniaturization of large-scale devices and laboratory-based procedures, enabling complex chemical and biological operations that are conventionally performed at the macro-scale to be carried out on the microscale or less. The advantages microfluidic systems offer such as rapid, low-cost, accurate, and on-site solutions make these tools extremely useful and effective in the fight against COVID-19. In particular, microfluidic-assisted systems are of great interest in different COVID-19-related domains, varying from direct and indirect detection of COVID-19 infections to drug and vaccine discovery and their targeted delivery. Here, we review recent advances in the use of microfluidic platforms to diagnose, treat or prevent COVID-19. We start by summarizing recent microfluidic-based diagnostic solutions applicable to COVID-19. We then highlight the key roles microfluidics play in developing COVID-19 vaccines and testing how vaccine candidates perform, with a focus on RNA-delivery technologies and nano-carriers. Next, microfluidic-based efforts devoted to assessing the efficacy of potential COVID-19 drugs, either repurposed or new, and their targeted delivery to infected sites are summarized. We conclude by providing future perspectives and research directions that are critical to effectively prevent or respond to future pandemics.

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基于微流控技术的COVID-19诊断、预防和治疗:最新进展和未来方向

COVID-19大流行对世界各地现有的医疗保健系统构成了重大挑战。由于迫切需要制定COVID-19的诊断和治疗策略，对新技术的需求蓬勃发展，这些新技术可以改善现有的医疗保健方法，朝着更先进、数字化、个性化和以患者为导向的系统发展。基于微流体的技术涉及大型设备和实验室程序的小型化，使传统上在宏观尺度上进行的复杂化学和生物操作能够在微观尺度或更小的尺度上进行。微流体系统提供的快速、低成本、准确和现场解决方案等优势使这些工具在对抗COVID-19方面非常有用和有效。特别是，微流体辅助系统在不同的COVID-19相关领域具有很大的兴趣，从COVID-19感染的直接和间接检测到药物和疫苗的发现及其靶向递送。在这里，我们回顾了使用微流控平台诊断、治疗或预防COVID-19的最新进展。我们首先总结了最近适用于COVID-19的基于微流体的诊断解决方案。然后，我们强调了微流体在开发COVID-19疫苗和测试候选疫苗中的关键作用，重点是rna递送技术和纳米载体。接下来，总结了基于微流体的研究成果，用于评估潜在的COVID-19药物(无论是重新利用的还是新的)的疗效，以及它们对感染部位的靶向递送。最后，我们提出了对有效预防或应对未来流行病至关重要的未来观点和研究方向。图形抽象

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来源期刊

Biomedical Microdevices 工程技术-工程：生物医学

CiteScore

6.90

自引率

3.60%

发文量

审稿时长

6 months

期刊介绍： Biomedical Microdevices: BioMEMS and Biomedical Nanotechnology is an interdisciplinary periodical devoted to all aspects of research in the medical diagnostic and therapeutic applications of Micro-Electro-Mechanical Systems (BioMEMS) and nanotechnology for medicine and biology. General subjects of interest include the design, characterization, testing, modeling and clinical validation of microfabricated systems, and their integration on-chip and in larger functional units. The specific interests of the Journal include systems for neural stimulation and recording, bioseparation technologies such as nanofilters and electrophoretic equipment, miniaturized analytic and DNA identification systems, biosensors, and micro/nanotechnologies for cell and tissue research, tissue engineering, cell transplantation, and the controlled release of drugs and biological molecules. Contributions reporting on fundamental and applied investigations of the material science, biochemistry, and physics of biomedical microdevices and nanotechnology are encouraged. A non-exhaustive list of fields of interest includes: nanoparticle synthesis, characterization, and validation of therapeutic or imaging efficacy in animal models; biocompatibility; biochemical modification of microfabricated devices, with reference to non-specific protein adsorption, and the active immobilization and patterning of proteins on micro/nanofabricated surfaces; the dynamics of fluids in micro-and-nano-fabricated channels; the electromechanical and structural response of micro/nanofabricated systems; the interactions of microdevices with cells and tissues, including biocompatibility and biodegradation studies; variations in the characteristics of the systems as a function of the micro/nanofabrication parameters.