Phytochemical Evaluation of Extracts and Pharmacological Activity of Polyherbal Emulgel

Q3 Pharmacology, Toxicology and Pharmaceutics International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-06-25 DOI:10.25258/ijpqa.14.2.17

Jitendra Kandale, J. Sangshetti, P. Mahaparale, G. Dama, J. Bidkar

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Abstract

Ocimum sanctum, Rubia cordifolia, Glycyrrhiza glabra, and Punica granatum are all used to treat various diseases and conditions in Ayurvedic medicine. In this study, we aimed to formulate and evaluate a polyherbal emulgel containing extracts from four different medicinal plants: O. sanctum, R. cordifolia, G. glabra, and P. granatum. Different gel formulations were created by combining a base component with extracts from O. sanctum, R. cordifolia, G. glabra, and P. granatum. pH, viscosity, rheology, appearance, and homogeneity were some of the criteria examined for each formulation. They were tested for evaporation and irritation of the epidermis with patches. The cup plate method was used to examine the antibacterial-antifungal activity of formulations against Escherichia coli, Pseudomonas aeruginosa, and Aspergillus niger. Results showed that the inhibition zones produced by all formulations were greater than those produced by the control. Antimicrobial characteristics can be found in polyherbal gels. Synergy between the plant components in the blend produced the desirable outcome.

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多草药乳液提取物的植物化学评价及药理活性

在阿育吠陀医学中，茴香、芦花、甘草和石榴都被用来治疗各种疾病和病症。在这项研究中，我们的目的是制备和评价一种含有四种不同药用植物提取物的多草药乳液:O. sanctum, R. cordifolia, G. glabra和P. granatum。不同的凝胶配方是通过将一种基础成分与圣草、堇青花、光天化日和石榴的提取物结合而成的。pH值，粘度，流变性，外观和均匀性是每个配方检查的一些标准。他们被测试蒸发和刺激表皮斑块。采用杯盘法检测制剂对大肠杆菌、铜绿假单胞菌和黑曲霉的抑菌抑菌活性。结果表明，各剂型的抑菌带均大于对照。抗菌特性可以在多草药凝胶中找到。混合物中植物组分之间的协同作用产生了期望的结果。

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International Journal of Pharmaceutical Quality Assurance Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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0.80

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期刊介绍： INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE is a quarterly international journal publishing the finest peer-reviewed research in the field of Pharmaceutical Quality Assurance and Pharmaceutical Analysis on the basis of its originality, importance, disciplinary interest, timeliness, accessibility, elegance, and surprising conclusions. IJPQA also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.